The authors analyzed 380 autopsies for chronic glomerulo- and pyelonephritis and studied the clinical and functional features of gastric pathology in 240 patients with the same disease entities. The hypotheses are suggested about a 3-stage successive formation of uremic gastropathy. The importance of hypergastrinemia as one of the pathogenetic factors, as a vicarious organ as regards nitrogenous products at early stages of chronic renal insufficiency is discussed.
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Kardiologiia
April 2017
Voronezh Medical State Aademy Named After N.N. Burdenko, Voronezh, Russia.
Close relationship between cardiovascular diseases and chronic obstructive pulmonary disease (COPD) has attracted attention over the past 15 years as one of the aspects of systemic manifestations of COPD. The high prevalence of cardiovascular diseases in patients with COPD is explained within the concept of low-level persistent systemic inflammation. This review presents current data on the prevalence of cardiovascular diseases and mortality in the population of patients with COPD.
View Article and Find Full Text PDFAmong the first detected patients, there was a reduction in the proportion of subjects with posttuberculous changes in the lung decreases in the presence of the deteriorating epidemiological situation. Risk factors of social diseases are of much importance in the development of tuberculosis at present. Infiltrative processes with lung tissue destruction and bronchogenic dissemination are essential in the clinical pattern of the disease.
View Article and Find Full Text PDFRetrospective and prospective epidemiologic studies revealed features of pathomorphosis and response, defined various pathogenetic mechanisms induced by complex, combined exposure to poisons at work. The article determined main neurologic and hematologic syndromes considered as early and sensitive diagnostic criteria of poisons influence on workers exposed to them. The authors described some variants of course and long-term complications of prolonged exposure to poisons.
View Article and Find Full Text PDFThe authors studied specific viral sensibilization and autoimmune processes in the pathogenesis of acute and protracted forms of viral hepatitis B. Combination of pronounced indices of virus-specific sensibilization and autosensibilization to the liver tissue without any tendency to reduction of the disease in its dynamics evidences the formation of severe and protracted course of viral hepatitis B.
View Article and Find Full Text PDFThe examination of 241 gout patients (207 males and 34 females) revealed a marked sexual dimorphism of the disease related to the articular and renal syndromes. Male gout is characterized by higher blood levels of uric acid and oxypurinole in reduced clearance of the latter, while in female gout there were hyperxanthinoxidasemia and hypo-cAMPemia. Unbalance of sex and gonadotropic hormones, which appeared multidirectional and dependent on the sex, was observed in males in the form of lower concentrations of blood testosterone and estradiol against elevated levels of progesterone and lutropin, in females manifested with hypoprogesteronemia and reduced gonadotropin.
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