Two cases of temporal arteritis are described. In patient K., aged 79 years, the disease ran an acute course and resulted in bilateral blindness. In patient T., aged 67 years, the disease ran a subacute course with a unilateral amaurosis and involvement into the disease of the cerebellar, humeral, renal, leg and, possibly, heart arteries. Elevation of the amount of circulating immune complexes in patient K. and no elevation in patient T, with the complement content being within normal, can be viewed as features of the disease progress.
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Behav Neurosci
January 2025
Department of Psychology and Program in Neuroscience, Providence College.
The posterior parietal cortex (PPC) is an associative neocortical region that integrates multiple streams of information and is implicated in spatial cognition and decision making. In some cases, however, the PPC is not required for these functions. One possibility is that the PPC is recruited when spatial complexity is high.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
Instituto Neurológico de Colombia, Medellin, Antioquia, Colombia.
Background: This study examines an exceptional case of CADASIL (Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy), a hereditary cerebrovascular disease caused by a mutation in the notch3 gene. In contrast to typical cases manifesting before the age of 50 with migraines, this report highlights an atypical presentation in a 70-year-old woman with no history of migraines nor cognitive impairment.
Method: The patient, with a history of type 2 diabetes, hypothyroidism, and dyslipidemia, was initially treated for cognitive impairment and behavioral changes under suspicion of autoimmune encephalitis.
Alzheimers Dement
December 2024
Reina Sofia Alzheimer Centre, CIEN Foundation, ISCIII, Madrid, Spain.
Background: About 20-30% of clinically diagnosed AD dementia patients do not meet pathologic criteria for AD and this proportion is even higher in amnestic MCI. Among tau-negative amnestic patients, limbic-predominant age-related TDP-43 encephalopathy (LATE) has been described as a principal diagnostic alternative, especially at advanced age. LATE is characterized by a specific temporo-limbic hypometabolic signature on FDG-PET that may aid in differential diagnosis.
View Article and Find Full Text PDFBackground: Altered network synchronization and rhythmic neural activity is observed in Alzheimer's disease (AD). Spontaneous epileptiform activity and/or seizures occur in an estimated 60% of AD cases, and having AD increases the likelihood of seizures when compared with people without dementia. Thus, network hyperexcitability can be an early feature and helpful for diagnosis and treatment.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
Division of Clinical Geriatrics, Center for Alzheimer Research, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden.
Background: Although β-amyloid and tau PET positivity (A+T+) has been related to neurodegeneration and cognitive decline in Alzheimer's disease (AD), the driving force of neurodegeneration in discordant AT cases remains controversial. We investigated the impact of AT status on longitudinal rates of cortical atrophy and cognitive decline.
Method: A subset of 349 individuals (cognitively unimpaired [CU; n=230], cognitively impaired [CI; n=119]) with β-amyloid and tau PET (a priori baseline), longitudinal MRI (interval; Mean=4.
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