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Impact of sleep restriction on biomarkers of thyroid function: Two pooled randomized trials.
Sleep Med
December 2024
Center of Excellence for Sleep & Circadian Research, Department of Medicine, Columbia University Irving Medical Center, New York, NY, USA; Division of General Medicine, Department of Medicine, Columbia University Irving Medical Center, New York, NY, USA. Electronic address:
Article Synopsis
- - Chronic mild sleep restriction (SR) for 6 weeks does not significantly affect levels of free thyroxine (FT4) or thyroid-stimulating hormone (TSH) in adults, but shows a potential sex difference with TSH reductions noted in women only.
- - The study involved 30 healthy participants (mostly women, with diverse racial/ethnic backgrounds), and measured hormonal levels before and after the AS (adequate sleep) and SR phases through blood samples.
- - Results suggest that while FT4 and fibroblast growth factor-21 (FGF-21) are unchanged, sustained mild sleep restriction might disrupt the regulation of TSH in women, which could be linked to higher cardiometabolic risks compared to
Peripheral precocious puberty secondary to severe hypothyroidism.
Arch Argent Pediatr
November 2024
Endocrinology Research Center Dr. César Bergadá, National Scientific Research Council and Techniques - FEI, Endocrinology Division; Hospital de General de Niños Ricardo Gutiérrez, City of Buenos Aires, Argentina.
Van Wyk-Grumbach syndrome is a rare form of severe hypothyroidism. We present a 10.9-year-old girl who consulted for genital bleeding, Tanner stage 2, and clinical manifestations of hypothyroidism.
View Article and Find Full Text PDFRebound effect of hypothalamic-pituitary thyreotropic activity: a new model to better understand hypothyroidism.
J Endocrinol Invest
October 2024
Endocrinology Section, Department of Clinical and Experimental Medicine, Garibaldi Nesima Hospital, University of Catania, Catania, Italy.
Purpose: Hypothalamic-pituitary thyrotropic activity (HPta) is crucial since TSH is the mainstay for evaluating primary hypothyroidism (hT) and replacement therapy in clinical practice. Despite TSH values, some patients experience symptoms and metabolic alterations, raising several issues about hT. The aim of the study was to investigate factors influencing the TSH values achieved after a period of hT induced in a standardized and controlled manner (TSH_time1).
View Article and Find Full Text PDFBone complications of cancer treatment.
Cancer Treat Rev
November 2024
State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Chinese Academy of Medical Sciences Research Unit of Oral Carcinogenesis and Management, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China.
With the advancements in conventional treatment modalities such as radiation, chemotherapy, and surgery, as well as the emergence of immunotherapy, the overall cure rate for solid tumor malignancies has experienced a significant increase. However, it is unfortunate that exposure to cancer treatments can have detrimental effects on the function of osteoblasts and osteoclasts, disturbing bone metabolic homeostasis in patients, as well as causing damage to bone marrow cells and other bone tissues. Consequently, certain tumor treatment options may pose a risk for subsequent bone diseases.
View Article and Find Full Text PDFLow Levels of Cortisol are Associated with HIV Infection in Older People: A Hormonal Substudy in the OVER50 Cohort.
Curr HIV Res
November 2024
Fundació Lluita contra les Infeccions, Hospital Germans Trias i Pujol, Badalona, Spain.
Introduction: People with the human immunodeficiency virus (PWH) who were diagnosed long ago are more prone to age-related conditions and comorbidities than the general population. We hypothesized that older PWH have endocrine abnormalities that may influence the patient's health status.
Methods: Mean hormonal values across the thyrotropic, somatotropic, corticotropic, and gonadal axis, and percentage of subjects with abnormal values, were compared between PWH aged ≥50 years (n=30) and people without HIV (n=30) (Over50 cohort).
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