Treatment of 23 hypertensive patients with labetalol at 200 mg twice daily for 3 months resulted in a 15-17% reduction in diastolic and systolic blood pressure, a significant amelioration in the PEP/LVET ratio expressing the haemodynamic performance of the left ventricle, and a significant reduction in its hypertrophy as expressed by the Romhilt-Estes index.
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