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Interplay between BMI, neutrophil, triglyceride and uric acid: a case-control study and bidirectional multivariate mendelian randomization analysis.
Nutr Metab (Lond)
January 2025
School of Basic Medical Sciences, Hubei University of Chinese Medicine, Wuhan, Hubei, 430065, China.
Background: This study aims to explore the interplay between body mass index (BMI), neutrophils, triglyceride levels, and uric acid (UA). Understanding the causal correlation between UA and health indicators, specifically its association with the body's inflammatory conditions, is crucial for preventing and managing various diseases.
Methods: A retrospective analysis was conducted on 4,286 cases utilizing the Spearman correlation method.
CXCR4 promotes tumor stemness maintenance and CDK4/6 inhibitors resistance in ER-positive breast cancer.
Breast Cancer Res
January 2025
Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, 510120, China.
Background: CDK4/6 inhibitors have significantly improved the survival of patients with HR-positive/HER2-negative breast cancer, becoming a first-line treatment option. However, the development of resistance to these inhibitors is inevitable. To address this challenge, novel strategies are required to overcome resistance, necessitating a deeper understanding of its mechanisms.
View Article and Find Full Text PDFPrevalence and morphology of middle mesial canals in mandibular first molars and their relationship with anatomical aspects of the mesial root: a CBCT analysis.
BMC Oral Health
January 2025
Department of Endodontics, Shaanxi Provincial People's Hospital, Xi'an, China.
Background: This study aims to investigate the prevalence and morphology of middle mesial canal (MMC) in mandibular first molar (M1M) among a Northwestern Chinese population, and to analyze their relationship with anatomical aspects of the mesial root.
Methods: Cone beam computed tomography (CBCT) was utilized to evaluate 898 M1Ms and assess the incidence and morphology of MMC. The following parameters for M1M with or without MMC were obtained: the vertical distance between the first appearance of MMC and canal orifices (D), the distance between mesiobuccal (MB) and mesiolingual (ML) canals (D1), the buccolingual width(L1) and mesiodistal width (L2) of mesial roots, and the flatness degree(L1/L2) of mesial roots.
hERGAT: predicting hERG blockers using graph attention mechanism through atom- and molecule-level interaction analyses.
J Cheminform
January 2025
Department of Intelligent Electronics and Computer Engineering, Chonnam National University, Gwangju, Republic of Korea.
The human ether-a-go-go-related gene (hERG) channel plays a critical role in the electrical activity of the heart, and its blockers can cause serious cardiotoxic effects. Thus, screening for hERG channel blockers is a crucial step in the drug development process. Many in silico models have been developed to predict hERG blockers, which can efficiently save time and resources.
View Article and Find Full Text PDFAssociation between some environmental risk factors and attention-deficit hyperactivity disorder among children in Egypt: a case-control study.
Ital J Pediatr
January 2025
High Institute of Public Health, Alexandria University, Alexandria, Egypt.
Background: Attention-Deficit Hyperactivity Disorder (ADHD) is a complex disease that negatively impacts the social and academic/occupational activities of children and is more common in boys than in girls.
Methods: This case-control study aimed to assess the association between some environmental risk factors and ADHD among children in Alexandria, Egypt. It was carried out at the outpatient clinics of El Shatby Pediatric University Hospital in Alexandria, Egypt, with 252 children (126 cases and 126 controls).
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