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Analysis of a Series of 26 Cases With Prenatal Skeletal Dysplasia via Multiplatform Genetic Detection.
Mol Genet Genomic Med
January 2025
Prenatal Diagnosis Center, Langfang Maternal and Child Health Care Hospital, Langfang, Hebei, China.
Background: Skeletal dysplasia (SD) represents a series of highly heterogeneous congenital genetic diseases affecting the human skeletal system. Refined genetic diagnosis is helpful for the accurate diagnosis and prognosis evaluation of SDs.
Materials And Methods: In this study, we recruited 26 cases of SD and analyzed them with a designed sequential genetic detection.
Engineering Planar Crystallinity in Nitrogen-Vacancy-Incorporated Carbon Nitride for Efficient Photoredox Catalysis.
ACS Appl Mater Interfaces
January 2025
Key Laboratory of Functional Inorganic Material Chemistry, Ministry of Education of the People's Republic of China, School of Chemistry and Materials Science, Heilongjiang University, Harbin 150080, People's Republic of China.
The concurrent evolution of value-added benzimidazole compounds and hydrogen within the domain of chemical synthesis is of paramount importance. The utilization of photocatalysis enhances both the efficiency and environmental benignity of the synthetic process. However, it is profoundly challenging within a photocatalytic system to simultaneously augment the number of active sites and the internal transport rate of photogenerated charge carriers.
View Article and Find Full Text PDFPersonality traits, mindfulness, and perceived stress in Chinese adults: a sequential explanatory mixed-methods approach.
Front Psychol
January 2025
Faculty of Public Administration, Guizhou University of Finance and Economics, Guiyang, China.
Background: This study explores how personality traits and mindfulness facets interact to influence perceived stress, focusing on a Chinese adult sample. It aims to address gaps in understanding the combined effects of dispositional and mindfulness factors on stress.
Methods: A sequential explanatory mixed-methods design was employed.
Prediction of early postoperative recurrence of hepatocellular carcinoma by habitat analysis based on different sequence of contrast-enhanced CT.
Front Oncol
January 2025
Department of Hepatobiliary Surgery, General Hospital of Ningxia Medical University, Yinchuan, China.
Aim: To develop a habitat imaging method for preoperative prediction of early postoperative recurrence of hepatocellular carcinoma.
Methods: A retrospective cohort study was conducted to collect data on 344 patients who underwent liver resection for HCC. The internal subregion of the tumor was objectively delineated and the clinical features were also analyzed to construct clinical models.
One-Pot Synthesis of 2-Substituted Indoles and 7-Azaindoles Sequential Alkynylation and Cyclization of 2-Iodo--mesylarylamines and Alkynes in the Presence of CuO.
Asian J Org Chem
January 2025
Department of Medicinal Chemistry, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, 160 Frelinghuysen Road, Piscataway, New Jersey 08854, USA.
A one-pot process was developed to synthesize in moderate to high yield a series of 2-substituted indoles and 7-azaindoles starting from 2-iodo--mesylarylamines and terminal alkynes in the presence of CuO in DMF at 90-120 °C. Without isolation of any intermediate, our optimized conditions enabled the introduction of ester, phenyl, hydroxymethyl, hydroxyethyl, -Boc-aminomethyl, and methyl at the 2-postion of indoles and 7-azaindoles. The reaction tolerates a variety of substrates containing halogens, or acid- or base-sensitive functional groups without requiring a Pd catalyst, a ligand, or a base.
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