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Intraventricular Administration of Exosomes from Patients with Amyotrophic Lateral Sclerosis Provokes Motor Neuron Disease in Mice.
Acta Naturae
January 2024
Research Center of neurology, Ministry of Science and Higher Education of the Russian Federation, Moscow, 125367 Russian Federation.
Amyotrophic lateral sclerosis (ALS) is a severe disease of the central nervous system (CNS) characterized by motor neuron damage leading to death from respiratory failure. The neurodegenerative process in ALS is characterized by an accumulation of aberrant proteins (TDP-43, SOD1, etc.) in CNS cells.
View Article and Find Full Text PDFExperimental Study on Myocardial Protective Effect of Xuebijing Injection on Extracorporeal Membrane Oxygenation Perfused Isolated Heart: Based on Autophagy and NLRP3 Inflammatory Pathway.
Transplant Proc
January 2025
Guangxi Medical University, Nanning, China. Electronic address:
Background: The purpose of this study was to investigate the myocardial protective effect of Xuebijing (XBJ) injection in isolated donor heart preservation based on autophagy and NLRP3 inflammatory pathway, and to provide clues for improving the quality of donor heart preservation in the clinic.
Methods: Fourteen Guangxi Bama miniature pigs were randomly divided into two groups to establish the isolated heart perfusion model of extracorporeal membrane oxygenation (ECMO): (1) normal saline group (NS group): 50 mL normal saline was added to the perfusion solution; and (2) Xuebijing injection group (XBJ group): 10 mL of XBJ was added to the perfusate. Both groups were continuously pumped with 5 mL/h for 8 hours.
Eruptive Syringoma-Clinical, Dermoscopic, and Reflectance Confocal Microscopy Features.
Diagnostics (Basel)
January 2025
Department of Dermatology, Venereology and Allergology, Medical University of Gdańsk, 80-214 Gdańsk, Poland.
We present an interesting image of eruptive syringoma confirmed by histopathological assessment in a 37-year-old male who was consulted due to numerous brownish small macules and papules resembling maculopapular cutaneous mastocytosis (MPCM). We show difficulties in diagnosing ES, given its rare occurrence and resemblance to other dermatological disorders. Moreover, we discuss the role of dermoscopy and reflectance confocal microscopy in the differential diagnosis of syringoma.
View Article and Find Full Text PDFIgE-based analysis of sensitization and cross-reactivity to yellow mealworm and edible insect allergens before their widespread dietary introduction.
Sci Rep
January 2025
Department of Experimental Allergology and Immunology, Medical University of Bialystok, Bialystok, Poland.
The European Commission authorized the use of dried yellow mealworm (Tenebrio molitor - TM) as a food ingredient under Regulation EU 2021/882. As TM emerges as an important allergen source, sensitization and allergy to TM in various populations need investigation. The aim of this study was to assess the incidence of sensitization to TM before its introduction as a food ingredient in Poland, as well as checking the occurrence of co-sensitivity to TM and other invertebrate allergenic extracts and molecules.
View Article and Find Full Text PDFMicrobiota of the Mammary Gland in Wistar Rats with Chemically Induced Breast Cancer after Treatment.
Bull Exp Biol Med
December 2024
Institute of Veterinary Medicine and Biotechnology, Novosibirsk State Agrarian University, Novosibirsk, Russia.
We conducted a comparative study of the mammary gland microbiota in female Wistar rats and the microbiota associated with breast cancer (BC) induced by the administration of N-methyl-N-nitrosourea, after surgical treatment, photodynamic therapy (PDT), and chemotherapy (CT). Selective nutrient media and a smear-fingerprint technique were used to study the microbiota. Staphylococcus, Streptococcus, and Lactobacillus were found in the mammary glands of intact rats.
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