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Listening to placebos: the contested lessons of antidepressants debates.
Hist Philos Life Sci
January 2025
University of Buenos Aires, Buenos Aires, Argentina.
The goal of this paper is to explore a set of epistemological and ontological issues regarding the historical and philosophical role of placebos in the contested history of antidepressants. Starting from an account of the dual nature of the placebo as both an epistemic and a therapeutic tool, and against the background of the heated debates on the efficacy of second-generation antidepressants, I propose two related arguments. First, I argue that placebos as controls played a crucial but paradoxical role in the rise of so-called evidence-based approaches to depression.
View Article and Find Full Text PDFCO2 Reduction at a Borane-Modified Iron Complex: A Secondary Coordination Sphere Strategy.
Angew Chem Int Ed Engl
January 2025
Western University, Chemistry, 1151 Richmond Street, N6A3K7, London, CANADA.
This work addresses fundamental questions that deepen our understanding of secondary coordination sphere effects on carbon dioxide (CO2) reduction using derivatized hydride analogues of the type, [Cp*Fe(diphosphine)H] (Cp* = C5Me5-) - a well-studied family of organometallic complex - as models. More precisely, we describe the general reactivity of [(Cp*-BR2)Fe(diphosphine)H], which contains an intramolecularly positioned Lewis acid, and its cooperative reactivity with CO2. Control experiments underscore the critical nature of borane incorporation for CO2 to reduced products, a reaction that does not occur for unfunctionalized [Cp*Fe(diphosphine)H]).
View Article and Find Full Text PDFEverything feels just a little heavier, more wrought with implications, you know? - a mixed-methods study examining lifestyle behaviors, health, and well-being of pregnant and postpartum women during the early months of the COVID-19 pandemic.
BMC Pregnancy Childbirth
January 2025
Department of Nutritional Sciences, School of Human Ecology, College of Natural Sciences, Department of Women's Health & Pediatrics, Dell Medical School, Dell Pediatric Research Institute, Population Research Center, The University of Texas at Austin, 1400 Barbara Jordan Blvd., Austin, TX, 78723, USA.
Background: While the striking impact of the COVID-19 pandemic on mental health, heath care access and lifestyle behaviors, including perceived health, diet, physical activity, and sleep has been reported, few studies have examined these domains jointly among pregnant and postpartum people in the early stages of the COVID-19 pandemic.
Methods: This mixed methods study was conducted among a subset of participants (n = 22) in a cohort study in Austin, Texas, who were pregnant or had recently delivered when the outbreak occurred. Measures were from the early second trimester up to 6 months postpartum.
Designing iron oxide & silver nanocomposites with phyto- and fungo chemicals for biomedicine: lessons learned.
J Mater Chem B
January 2025
NanoBioMedical Centre, Adam Mickiewicz University in Poznań, 61614 Poznań, Poland.
Article Synopsis
- Multifunctional nanoparticles derived from plants and mushrooms show potential for improved therapy and diagnostics in biomedicine.
- The combination of silver and natural phytochemicals has been found to enhance antimicrobial and anticancer effects, particularly in conjunction with photodynamic therapy.
- Gel formulations of these nanoparticles demonstrate greater effectiveness against cancer cells and adapt to tissue structures, indicating promising applications for targeted cancer treatment and tissue regeneration after surgeries.
Integrating environmental physiotherapy into New Zealand undergraduate education: exploring current practice.
Front Public Health
January 2025
Centre for Health, Activity, and Rehabilitation Research, School of Physiotherapy, University of Otago, Dunedin, New Zealand.
This paper describes the integration of environmental physiotherapy education into the physiotherapy curriculum in a New Zealand university in response to the environmental physiotherapy agenda and the University of Otago Sustainability Framework. We describe and discuss three learning activities, the associated challenges and lessons learnt, and the current position. Given the encompassing nature of environmental and health interactions, we aimed for multilayer immersive experiences using a range of pedagogical approaches.
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