Twenty-six patients aged between 27 and 71 years with chronic bronchitis were divided into a control group of 6 and two groups of 10 patients each who received either erythromycin stearate or amoxycillin 1500 mg/d for 2 weeks and 1000 mg/d for 12 weeks thereafter. Immunological function tests were performed before starting chemotherapy and thereafter at 2 weeks and 14 weeks. Clinical evaluations and lung function tests showed no significant changes in any of the groups during the study period. In the control group no changes in cellular and humoral immune functions were noted. In the group receiving amoxycillin decreased responses of lymphocytes to the mitogen phytohaemagglutinin were observed after 14 days. In the erythromycin-treated group, increased polymorphonuclear leucocyte (PMNL) motility and mitogen-induced transformation were observed at 14 days but these increases were not statistically significant. In this group the markedly depressed PMNL migration found in 3 individuals before treatment improved considerably. These results indicate that chemotherapy and chemoprophylaxis with either amoxycillin or erythromycin stearate do not compromise the host immunodefences.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Antibiotic prescribing trends in primary care 2014-2022.
Res Social Adm Pharm
August 2023
School of Computer Science and Mathematics, Liverpool John Moores University, James Parsons Building, Byrom St, Liverpool, L3 3AF, UK.
Antimicrobial resistance (AMR) is a global healthcare challenge that governments and health systems are tackling primarily through antimicrobial stewardship (AMS). This should, improve antibiotic use, avoid inappropriate prescribing, reduce prescription numbers, aligning with national/international AMS targets. In primary care in the United Kingdom (UK) antibiotics are mainly prescribed for patients with urinary and respiratory symptoms (22.
View Article and Find Full Text PDFDevelopment and validation of a stability indicating HPLC method for organic impurities of erythromycin stearate tablets.
J Pharm Biomed Anal
February 2021
Compendial Development Laboratory, United States Pharmacopeial Convention (USP), 12601 Twinbrook Parkway, Rockville, MD, 20852, USA.
A rapid, sensitive, and accurate high-performance liquid chromatography (HPLC) method was developed and validated for the separation and analysis of organic impurities in erythromycin stearate tablets. The method separates Erythromycin, Erythromycin B, Erythromycin C and nine impurities (EP Impurity A, B, C, D, E, F, H, I and M). The chromatographic separation was achieved on a Waters XBridge C18 (100 mm × 4.
View Article and Find Full Text PDFA new lipid-based oral delivery system of erythromycin for prolong sustain release activity.
Mater Sci Eng C Mater Biol Appl
April 2019
National Institute for Pharmaceutical Research and Development (NIPRD), Idu, Abuja, Nigeria.
Erythromycin-loaded solid lipid microparticles (SLM) based on solidified reverse micellar solution (SRMS) as an oral delivery formulation was studied. Hot homogenization technique was employed to prepare erythromycin stearate-loaded SLMs using blends of Softisan® 154 and Phospholipon® 90H or beeswax in the ratio of 1:2, and characterized in vitro. Antibacterial evaluation of the formulations was carried out by agar diffusion technique against some selected clinical isolates of bacterial.
View Article and Find Full Text PDFDevelopment of pH sensitive polymeric nanoparticles of erythromycin stearate.
J Pharm Bioallied Sci
May 2016
Formulation Development, Ipca Laboratories Limited, Mumbai, Maharashtra, India.
Context: Bioavailability of conventional tablet of erythromycin stearate is low as it is unstable at acidic pH and also shows a low dissolution rate.
Objective: It was proposed to protect it from the acidic condition of the stomach along with an increase in dissolution rate by formulating pH sensitive nanoparticles.
Materials And Methods: The nanoparticles were prepared by the solvent evaporation technique using different quantities of Eudragit L100-55 and polyvinyl alcohol (PVA).
TEMPO-oxidized Konjac glucomannan as appliance for the preparation of hard capsules.
Carbohydr Polym
June 2016
College of Life Science and Technology, Beijing University of Chemical Technology, Beijing 100029, China; Beijing Advanced Innovation Center for Food Nutrition and Human Health, Key Laboratory of Functional Dairy, College of Food Science and Nutritional Engineering, China Agricultural University, Beijing 100083, China. Electronic address:
Article Synopsis
- TEMPO-oxidized Konjac glucomannan (OKGM) was created as a new vegetarian option for hard capsules, tested at various oxidation levels (DO30%, DO50%, DO80%) to determine the best for capsule formation.
- FT-IR and XRD analyses showed that oxidation converted primary alcohols to carboxyl groups and reduced KGM's crystallinity, with DO80% proving optimal due to improved solubility, transparency, and reduced viscosity.
- DO80% OKGM capsules exhibited enhanced film properties, such as increased hydrophilicity and tensile strength, with a drug release profile indicating shell rupture in 5-10 minutes and 80% drug release in 30-
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!