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Anthelmintic activity and pathophysiological effect of Allium sativum crude extract against carcinogenic liver fluke, Opisthorchis viverrini.
Trop Biomed
December 2024
Parasitic Disease Research Center, Suranaree University of Technology, Nakhon Ratchasima 30000, Thailand.
Opisthorchis viverrini poses a substantial risk for cholangiocarcinoma (CCA) in Thailand. Despite praziquantel (PZQ) remains the primary treatment for opisthorchiasis, its association with adverse effects and potential CCA development during prolonged treatment, particularly in cases of reinfection and chronic infection, underscores the imperative for alternative herbal interventions with anthelmintic potential. In this context, a prior study suggested the inhibitory effects of Allium sativum L.
View Article and Find Full Text PDFBiomarker potential of plasma cell-free DNA for cholangiocarcinoma.
Heliyon
December 2024
Research Group in Multidimensional Health and Disease (MHD), Chulabhorn International College of Medicine, Thammasat University, Pathum Thani, 12120, Thailand.
Background: To prevent the development of cholangiocarcinoma, an effective screening opisthorchiasis viverrini and/or differential diagnosis of and the cholangiocarcinoma is crucial needed. The level and quality of cfDNA in plasma are being investigated for their potential role as biomarkers in cholangiocarcinoma.
Methods: The study enrolled 43 healthy controls (N), 36 -infected subjects (OV), and 36 cholangiocarcinoma patients (CCA).
Environmental Management for Opisthorchis viverrini and Cholangiocarcinoma Prevention in a High-Risk Area of Thailand: The KALMeFS Model.
Asian Pac J Cancer Prev
December 2024
Department of Community Health, Faculty of Public Health, Ubon Ratchathani Rajabhat University, Ubon Ratchathani, Thailand.
Objective: Despite the Ministry of Public Health's initiative to involve local governments in waste management through the establishment of sewage treatment ponds aimed at disrupting the life cycle of Opisthorchis viverrini (OV), the majority of areas still lack adequate sewage treatment facilities. This action research sought to develop an environmental management model (EMM) to prevent OV and cholangiocarcinoma (CCA) in a high-risk region of Thailand.
Methods: The study identified two primary target groups: a process development group comprising 20 participants and an evaluation group comprising 32 participants.
Environmental contamination of eggs and its impact on transmission control in rural northeast Thailand.
Infect Dis (Lond)
December 2024
Department of Biology, The Parasitology, Geoinformatics, Environment and Health Science research group, Faculty of Science, Udon Thani Rajabhat University, Udon Thani, Thailand.
Background: Environmental contamination with eggs significantly impacts on opisthorchiasis transmission and disease control. This study assessed egg contamination in underwater sediments from canals and aimed to reduce transmission in egg-positive and downstream communities by controlling human opisthorchiasis in endemic area of Northeast Thailand.
Methods: Sediment samples from 14 sites in UdonThani municipality were determined for eggs.
Differential circulating miRNA profiles identified miR-423-5p, miR-93-5p, and miR-4532 as potential biomarkers for cholangiocarcinoma diagnosis.
PeerJ
December 2024
Chulabhorn International College of Medicine (CICM), Thammasat University, Pathum Thani, Thailand.
Background: Cholangiocarcinoma (CCA) is high in morbidity and mortality rates which may be due to asymptomatic and effective diagnostic methods not available. Therefore, an effective diagnosis is urgently needed.
Methods: Investigation of plasma circulating miRNA (cir-miRNA) was divided into two phases, including the discovery phase (pooled 10 samples each from three pools in each group) and the validation phase (17, 16, and 35 subjects of healthy control (HC), (OV), and CCA groups, respectively).
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