A case report is given of a patient who developed adenocarcinoma of the colon 20 years after ureterosigmoidostomy, which had been done because of exstrophy of the bladder. A review of the literature is given covering 42 cases showing development of tumors after ureterosigmoidostomy. Possible causal mechanisms are discussed. A careful follow-up of patients with ureterosigmoidostomy is warranted, since malignant disease of the colon may occur as a late complication.

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