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Intragastric restructuring dictates the digestive kinetics of heat-set milk protein gels of contrasting textures.
Food Res Int
November 2024
Riddet Institute, Massey University, Private Bag 11 222, Palmerston North 4442, New Zealand.
The gelation of milk proteins can be achieved by various means, enabling the development of diverse products. In this study, heat-set milk protein gels (15 % protein) of diverse textures were made by pH modulation and two gels were selected for dynamic in vitro gastric digestion: a spoonable soft gel (SG, pH 6.55' G' of ∼100 Pa) and a sliceable firm gel (FG, pH 5.
View Article and Find Full Text PDFDiscovery of an orally effective double-stapled peptide for reducing ovariectomy-induced bone loss in mice.
Acta Pharm Sin B
September 2023
School of Pharmacy, Second Military Medical University, Shanghai 200433, China.
Stapled peptides with significantly enhanced pharmacological profiles have emerged as promising therapeutic molecules due to their remarkable resistance to proteolysis and performance to penetrate cells. The all-hydrocarbon peptide stapling technique has already widely adopted with great success, yielding numerous potent peptide-based molecules. Based on our prior efforts, we conceived and prepared a double-stapled peptide in this study, termed FRNC-1, which effectively attenuated the bone resorption capacity of mature osteoclasts through specific inhibition of phosphorylated GSK-3.
View Article and Find Full Text PDFImpact of alfalfa ( L.) galactomannan on the microstructural and physicochemical changes of milk proteins under static digestion conditions.
Food Chem X
June 2022
Environmental Research and Innovation (ERIN) Department, Luxembourg Institute of Science and Technology (LIST), 5 avenue des Hauts-Fourneaux, Esch-sur-Alzette, L4362, Luxembourg.
This paper reports on the impact of alfalfa galactomannan (AAG, 0.1, 0.5 or 1% wt.
View Article and Find Full Text PDFSpatial-temporal mapping of the intra-gastric pepsin concentration and proteolysis in pigs fed egg white gels.
Food Chem
September 2022
STLO, INRAE, Institut Agro, 65 rue de Saint-Brieuc, 35042 Rennes, France.
While there is a consensus that food structure affects food digestion, the underlying mechanisms remain poorly understood. A previous experiment in pigs fed egg white gels of same composition but different structures evidenced such effect on food gastric disintegration. In this study, we detailed the consequences on intra-gastric pH, pepsin concentration and proteolysis by sampling throughout the stomach over 6 h digestion.
View Article and Find Full Text PDFBerberine alleviates liver fibrosis through inducing ferrous redox to activate ROS-mediated hepatic stellate cells ferroptosis.
Cell Death Discov
December 2021
Department of Gastroenterology, The Third Affiliated Hospital of Sun Yat-Sen University, 510630, Guangzhou, China.
Berberine (BBR) has been explored as a potential anti-liver fibrosis agent, but the underlying mechanisms are unknown. In the current study, we aimed to investigate the molecular mechanisms underlying the effect of BBR against liver fibrogenesis in thioacetamide (TAA) and carbon tetrachloride (CCl) induced mouse liver fibrosis. In addition to i.
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