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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1440150PMC
http://dx.doi.org/10.1177/014107688407701209DOI Listing

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Article Synopsis
  • Mycosis fungoides (MF) is a rare skin cancer that progresses slowly in early stages but can vary greatly in treatment response and life expectancy once advanced.
  • The BIO-MUSE trial aims to identify specific markers for disease progression using advanced molecular analysis techniques, analyzing tissue and blood samples from a patient over time.
  • Findings highlight potential targets for treatment, such as transforming growth factor β1, suggesting that studying the cancer's evolution alongside the immune response may improve future interventions.
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Methotrexate (MTX), an antimetabolite targeting certain autoimmune conditions and various hematologic malignancies, has been associated with iatrogenic lymphoproliferative disease (LPD) primarily of B-cell lineage. Less commonly are T-cell neoplasms where primary skin involvement is considered rare. Three cases were encountered in the medical practice of one of the authors.

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Objective: To highlight the importance of early recognition of hypopigmented mycosis fungoides (HMF) in cases of cutaneous hypochromia in children, with a view to an effective diagnostic and therapeutic approach.

Case Description: Two cases of HMF in children are reported. The first case involves an eight-year-old boy with hypochromic macules on the trunk and root of the upper and lower limbs, while the second case is a six-year-old boy with widespread hypochromic patches.

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Background And Objectives: Patients with cutaneous lymphomas (CL) are at an increased risk of developing secondary malignancies. This study aimed to assess the frequency of association between CL and Kaposi sarcoma (KS) and to identify factors that may promote the co-occurrence of these two diseases.

Patients And Methods: On January 25, 2024, we conducted a systematic search of four electronic medical databases to identify all published cases of KS associated with CL.

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