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Light-dark shift promotes colon carcinogenesis through accelerated colon aging.
iScience
January 2025
Rush Center for Integrated Microbiome and Chronobiology Research, Rush University Medical Center Chicago, IL 60612, USA.
Colorectal cancer (CRC) is the third most common cancer worldwide, with rising prevalence among younger adults. Several lifestyle factors, particularly disruptions in circadian rhythms by light-dark (LD) shifts, are known to increase CRC risk. Epidemiological studies previously showed LD-shifts are associated with increased risk of CRC.
View Article and Find Full Text PDFBackground And Aims: Intestinal parasitic infection is a common disease that causes significant morbidity and mortality in developing countries, including Ethiopia. The burden of intestinal parasites is worse in schoolchildren, which leads to absenteeism from school, lower cognitive ability, affects academic performance, and causes malnutrition and anemia. While many studies have been reported, there is a paucity of published data in Debre Markos.
View Article and Find Full Text PDFRisks of parasitic helminth disease outbreaks and influence of physico-chemical factors in flood prone areas of Yaoundé, Cameroon.
Parasite Epidemiol Control
February 2025
Centre for Research on Health and Priority Pathologies, Institute of Medical Research and Medicinal Plants Studies, PO box 13033 Yaoundé, Cameroon.
Background: Urbanization coupled with poverty has promoted the exploitation of risk zones like flood-prone areas in the city of Yaoundé. The overcrowding and poor hygiene observed in these areas are responsible for the unsmiling variations in environmental cleanliness, exploitation of river water for domestic purposes thus putting them at risk for parasitic disease transmissions. This study was conducted in order to assess the risks of human helminthiases outbreaks in relation to water physico-chemical factors in the city of Yaoundé.
View Article and Find Full Text PDFPrevalence of medical conditions or comorbidities influencing first-line therapy in unresectable hepatocellular carcinoma in the United States.
Future Oncol
January 2025
Cardinal Health, Dublin, OH, USA.
Introduction: Given treatment landscape changes, understanding the prevalence of medical conditions/comorbidities influencing real-world unresectable hepatocellular carcinoma (uHCC) treatment decisions is key for improving outcomes.
Patients And Methods: In a retrospective chart review, physicians abstracted data from uHCC patients initiating first-line treatment (1L) between June 2020 and April 2022. Frequencies of medical conditions/comorbidities at 1L initiation were reported.
Comparison of the safety of esophagojejunal overlap and π-shaped anastomosis in totally laparoscopic total gastrectomy.
BMC Surg
January 2025
Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Gastrointestinal Surgery IV, Peking University Cancer Hospital & Institute, Beijing, 100142, China.
Background: Globally, totally laparoscopic total gastrectomy is increasingly being accepted by surgeons for the treatment of gastric cancer. Overlap anastomosis and π-shaped anastomosis are the two most commonly used anastomosis methods in total laparoscopic surgery; however, their safety and suitability for the population are still unclear.
Methods: A total of 162 consecutive patients with gastric cancer who underwent total laparoscopic total gastrectomy with overlap or π-shaped anastomosis were retrospectively analyzed.
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