The non-invasive photometric techniques recording the contraction-relaxation cycles demonstrate the absence of any lag period in pulsation of isolated veins in situ. Contractions are temporarily inhibited at the site of contact of the vein surface with a glass rod. This indicates that the results obtained with the techniques, in which glass sensors were used to detect the contractile activity, are not conclusive and provide no reliable data about the motive force generation site in plasmodium.
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http://dx.doi.org/10.1016/0309-1651(84)90065-1 | DOI Listing |
J Orthop Surg Res
January 2025
Academy of Medical Engineering and Translational Medicine, Tianjin University, Tianjin, 300072, China.
Background: Knee Osteoarthritis (KOA) is a prevalent condition worldwide, significantly diminishing quality of life and productivity. Except for the alignment change, muscle activation patterns (MAP) have garnered increasing attention as another crucial factor contributing to KOA.
Objective: This study explores the factors, characteristics, and effects of MAP changes caused by KOA, providing a neuromuscular-based causal analysis for the rehabilitation treatment of KOA.
Nat Commun
January 2025
Department of Bioengineering, Imperial College London, London, UK.
Robotic artificial muscles, inspired by the adaptability of biological muscles, outperform rigid robots in dynamic environments due to their flexibility. However, the intrinsic compliance of the soft actuators restricts force transmission capacity and dynamic response. Biological muscle modulates their stiffness and damping, varying viscoelastic properties and force in interaction with the surroundings.
View Article and Find Full Text PDFEur Respir J
January 2025
Université Paris-Saclay, INSERM Unité Mixte de Recherche en Santé 999 (HPPIT), Service de Pneumologie et Soins Intensifs Respiratoires, Hôpital Bicêtre (Assistance Publique-Hôpitaux de Paris), Le Kremlin-Bicêtre, France.
Introduction: Pulmonary arterial hypertension (PAH) is a progressive disease associated with significant morbidity and mortality. Sotatercept is a first-in-class activin signalling inhibitor that acts to restore the balance between the growth-promoting and growth-inhibiting signalling pathways.
Methods: This post-hoc, exploratory, pooled analysis combines data from the double-blind placebo periods of the phase 2 PULSAR (NCT03496207) and phase 3 STELLAR (NCT04576988) studies.
Int J Biol Macromol
January 2025
Department of Zoology, University of Kalyani, Kalyani, Nadia, West Bengal 741235, India. Electronic address:
The pathophysiological relationship between wound healing impairment and diabetes is an intricate process. Burn injury among diabetes patients leads to neurological, vascular, and immunological abnormalities along with impaired activities of cell proliferation, collagen production, growth factors, and cytokine activities with huge bacterial infestation. In our study, we aimed to achieve a burn wound dressing material with the help of electrospun Chitosan/Polyethylene oxide/Rosmarinic acid (CS/PEO/RA) nanofibers.
View Article and Find Full Text PDFAm J Physiol Heart Circ Physiol
January 2025
Université de Tours, Inserm UMR1327 ISCHEMIA Membrane Signalling and Inflammation in reperfusion injuries, Tours, France.
Pathological left ventricular remodeling is a complex process following an acute myocardial infarction, leading to architectural disorganization of the cardiac tissue. This phenomenon is characterized by sterile inflammation and the exaggerated development of fibrotic tissue, which is non-contractile and poorly conductive, responsible for organ dysfunction and heart failure. At present, specific therapies are lacking for both prevention and treatment of this condition, and no biomarkers are currently validated to identify at-risk patients.
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