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Leontiasis ossea in the setting of chronic kidney disease and limited dialysis access: A case report with discussion of therapeutic implications.
Radiol Case Rep
March 2025
Department of Family Medicine, University of South Florida, Morsani College of Medicine, Tampa, FL, USA.
Article Synopsis
- Leontiasis ossea, or craniofacial fibrous dysplasia, is a rare condition that causes abnormal growth of facial bones, often linked to chronic kidney disease and high parathyroid hormone levels.
- A case of a 30-year-old male with severe facial swelling and bone changes highlights the rapid progression of symptoms after poor dialysis access and the persistence of hyperparathyroidism despite treatment efforts.
- The article also reviews the underlying causes, imaging techniques used for diagnosis, and management strategies for this complex disease.
Assessing Changes in Non-Specific Symptoms after Parathyroidectomy for Primary Hyperparathyroidism using a Smartwatch.
Endocr Pract
December 2024
Department of Endocrine Surgery, Cleveland Clinic, Cleveland, Ohio. Electronic address:
Objective: Parathyroidectomy (PTX) is indicated in primary hyperparathyroidism (PHPT) with osteoporosis or nephrolithiasis. There is not a uniform consensus on the benefit of PTX for non-specific symptoms, but patient-reported questionnaires have demonstrated improved quality of life (QOL) afterwards. This study aimed to evaluate physical activity and sleep after PTX using smartwatch technology.
View Article and Find Full Text PDFEffect of Parathyroidectomy After Renal Transplantation on Grafted Kidney Function Within One Year: A Meta-Analysis.
Transplant Proc
December 2024
Organ Transplantation Department, The Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou, China. Electronic address:
Article Synopsis
- Secondary hyperparathyroidism (sHPT) is common in chronic kidney disease (CKD) patients, with many developing tertiary hyperparathyroidism (tHPT) after kidney transplantation.
- A meta-analysis of 12 studies investigated how parathyroidectomy (surgery to remove the parathyroid glands) affects kidney graft function one year after the procedure.
- Results showed a decline in kidney function, indicated by lower glomerular filtration rate and higher serum creatinine levels, suggesting that while calcium and parathyroid hormone levels normalized, the risk of graft loss increases after parathyroidectomy.
Surgical and Pathological Challenges in Thyroidectomy after Thermal Ablation of Thyroid Nodules.
Thyroid
December 2024
Department of Surgery, National Taiwan University Hospital, Taipei, Taiwan.
Article Synopsis
- Thermal ablation is a minimally invasive procedure used for treating benign thyroid nodules but raises concerns about difficulties in subsequent thyroid surgery and accurate pathological assessments.
- A study with 165 patients compared outcomes between those who had prior ablation and those who had not, finding that the ablation group experienced longer surgery times, higher difficulty scores, and more severe adhesions.
- Histopathological evaluations indicated significant tissue changes in the ablated areas, including inflammation and necrosis, which complicated the diagnosis of thyroid tumors, raising issues in identifying tumor boundaries and potential malignancy.
48-Year clinical experience and genetic analysis of pediatric primary hyperparathyroidism from a single center in China.
J Endocrinol Invest
November 2024
Key Laboratory of Endocrinology, Department of Endocrinology, Peking Union Medical College Hospital, Chinese Academy of Medical Science & Peking Union Medical College, No.1 Shuaifuyuan Wangfujing, Beijing, 100730, China.
Purpose: This study aims to investigate the clinical and genetic features and change of clinical spectrum of primary hyperparathyroidism (PHPT) in children and adolescents.
Methods: The clinical and follow-up data of 74 pediatric patients (onset age ≤ 18 years) with PHPT during 1975-2022 were retrospectively analyzed. For comparison, patients were divided into four subgroups according to their time of diagnosis.
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