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Impact of hospital formulary intervention on carbapenem use: a segmented time-series analysis of consumption and a propensity score-matched non-inferiority study of treatment efficacy.
J Pharm Health Care Sci
January 2025
Laboratory of Clinical Pharmacy Education, Research and Education Center for Clinical Pharmacy, School of Pharmacy, Kitasato University, 5-9-1, Shirokane, Minato-ku, Tokyo, 108-8641, Japan.
Background: Pharmaceutical formularies play a crucial role in guiding medication use by balancing clinical effectiveness and cost efficiency. Although formulary implementation has been increasing in Japan, comprehensive evaluations of its impact on both clinical and economic outcomes are limited. This study aimed to assess the effect of introducing an antimicrobial formulary at Yokohama City University Hospital on antibiotic usage and treatment outcomes in intra-abdominal infections.
View Article and Find Full Text PDFEPIDURAL ADMINISTRATION OF TRAMADOL DOES NOT PROVIDE SUFFICIENT INTRAOPERATIVE ANALGESIA FOR ELECTIVE OVARIOHYSTERECTOMY IN HEALTHY CATS.
Top Companion Anim Med
January 2025
Department of Small Animal Clinic, Centre of Rural Sciences, Federal University of Santa Maria (UFSM), Rio Grande do Sul State, Brazil.
Few studies today address trans-operative analgesia provided by tramadol without local anesthetics for intra-abdominal procedures. The objective of this study was to assess the efficacy of trans-operative analgesia provided by epidurally administered tramadol in cats undergoing elective ovariohysterectomy. For this purpose, 16 healthy queens were randomly assigned to participate in one of two groups: GC, control group, 0.
View Article and Find Full Text PDFKnockout or treatment with an antagonist of formyl peptide receptor 1 protects mice from sepsis by inhibiting inflammation.
Cytokine
January 2025
Department of Gastroenterology, General Hospital of Ningxia Medical University (The First Clinical Medical College of Ningxia Medical University), 750004 Yinchuan, China.
Background: Sepsis is an infection-related systemic inflammation with high mortality rates. Activation of formyl peptide receptor 1 (FPR1) in immune cells can promote their chemotaxis and inflammatory response, which imbalances immune response during the process of sepsis. FPR1 blockade did diminish systemic inflammatory response during bacterial infection.
View Article and Find Full Text PDFPopulation pharmacokinetics and pulmonary modeling of eravacycline and the determination of microbiological breakpoint and cutoff of PK/PD.
Antimicrob Agents Chemother
January 2025
Department of Clinical Pharmacy and Pharmacy Administration, School of Pharmacy, Fudan University, Shanghai, China.
Eravacycline is a broad-spectrum fluorocycline currently approved for complicated intra-abdominal infections (cIAIs). In lung-infection models, it is effective against methicillin-resistant (MRSA) and tetracycline-resistant MRSA. As such, we aimed to develop a population pharmacokinetic/pharmacodynamic (PK/PD) model to evaluate eravacycline's pulmonary distribution and kinetics.
View Article and Find Full Text PDFRisk prediction models for feeding intolerance in patients with enteral nutrition: a systematic review and meta-analysis.
Front Nutr
January 2025
Department of Epidemiology and Health Statistics, Tianjin Medical University, Tianjin, China.
Background: Although more risk prediction models are available for feeding intolerance in enteral-nourishment patients, it is still unclear how well these models will work in clinical settings. Future research faces challenges in validating model accuracy across populations, enhancing interpretability for clinical use, and overcoming dataset limitations.
Objective: To thoroughly examine studies that have been published on feeding intolerance risk prediction models for enteral nutrition patients.
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