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Intracellular trafficking of lipid nanoparticles is hindered by cholesterol.
Int J Pharm
January 2025
College of Pharmacy, DaLi University, No. 2 Hongsheng Road, Dali, Yunnan Province 671003, China; Yunnan Key Laboratory of Screening and Research on Anti-pathogenic Plant Resources from Western Yunnan, Dali University, Xueren Road, Dali, Yunnan Province 671003, China; Yunnan Provincial Key Laboratory of Entomological Biopharmaceutical R&D, College of Pharmacy, Dali University, Dali, Yunnan Province 671003, China. Electronic address:
The intracellular trafficking of lipid nanoparticles (LNPs) leading to endosomal escape is critical for delivery efficiency. How components of LNP affect its intracellular trafficking and delivery efficiency remains unknown. Here, we developed a highly sensitive LNP/nucleic acid tracking platform based on streptavidin-biotin-DNA complex and high throughput imaging.
View Article and Find Full Text PDFEffect of a spatial repellent on malaria incidence in an area of western Kenya characterised by high malaria transmission, insecticide resistance, and universal coverage of insecticide treated nets (part of the AEGIS Consortium): a cluster-randomised, controlled trial.
Lancet
January 2025
Department of Biological Sciences, Eck Institute for Global Health, University of Notre Dame, Notre Dame, IN, USA.
Background: Spatial repellent products are used for prevention of insect bites, and a body of evidence exists on spatial repellent entomological efficacy. A new option for vector control, spatial repellent products are designed to release active ingredient into the air for disruption of human-vector contact thereby reducing human exposure to mosquito-borne pathogens. Clinical trials have shown spatial repellent epidemiological efficacy against Aedes-borne viruses but inconclusive outcomes against malaria.
View Article and Find Full Text PDFComparison of the Physicochemical Properties, Microbial Communities, and Hydrocarbon Composition of Honeys Produced by Different Species.
Foods
November 2024
College of Animal Sciences, Zhejiang University, Hangzhou 310058, China.
The chemical composition and quality of honey are influenced by its botanical, geographic, and entomological origins, as well as climatic conditions. In this study, the physicochemical characteristics, microbial communities, and hydrocarbon compounds of honey produced by , , , , and were elucidated. The physicochemical profile of the honey exhibited significant differences across species, including moisture content (18.
View Article and Find Full Text PDFTherapeutic Potential of Bee and Wasp Venom in Anti-Arthritic Treatment: A Review.
Toxins (Basel)
October 2024
Yunnan Provincial Key Laboratory of Entomological Biopharmaceutical R&D, College of Pharmacy, Dali University, Dali 671000, China.
Arthritis has a high global prevalence. During the early ancient human era, bee () venom therapy was employed in Egypt, Greece, and China to alleviate ailments such as arthritis and neuralgia. In addition, bee venom has long been used as a traditional medicine for immune-related diseases in Korea.
View Article and Find Full Text PDFUncovering the Mechanism of Scopoletin in Ameliorating Psoriasis-Like Skin Symptoms via Inhibition of PI3K/Akt/mTOR Signaling Pathway.
Inflammation
November 2024
College of Pharmacy, Dali University, Dali, 671000, China.
Psoriasis is a common chronic inflammatory skin disease, that always seriously decreases the patient's quality of life. To date, the drugs used to treat psoriasis have severe side effects and poor efficacy, making the development of new drugs urgent. Scopoletin (SCP), a coumarin component extracted from plants such as Artemisia indica and Arabidopsis thaliana, was reported to have anti-inflammatory and immunomodulatory effects.
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