A subliminal psychodynamic activation experiment was conducted in which the effects of five subliminal stimuli were sought on the dart-throwing performance of male subjects. The stimuli consisted of the following messages, each accompanied by a congruent picture: BEATING DAD IS OK, BEATING DAD IS WRONG, BEATING HIM IS OK, BEATING HIM IS WRONG, and PEOPLE ARE WALKING. The first two stimuli were intended to activate competitive motives within the context of the Oedipus complex; the next two, competitive motives outside that context; and the last was intended as a control stimulus. BEATING DAD IS OK led to greater dart-throwing accuracy than each of the other four conditions, which in turn did not differ from each other. This finding replicated a result reported by Silverman, L. H., Ross, D., Adler, J., and Lustig, D. (J. Abnorm. Psychol., 87: 341-357, 1978) and is in keeping with the formulation that the activation of oedipal motives can affect competitive performance. Neither a subject variable (fear of success) nor the differential effects of two experimenters was found to interact with stimulus conditions in affecting dart scores.
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Int J Pharm
January 2024
Department of Pharmaceutics, Faculty of Pharmacy, Alexandria University, Egypt; Head of international publishing & nanotechnology consultation center INCC, Faculty of Pharmacy, Pharos university, Alexandria, Egypt. Electronic address:
Skin cancer is considered the fifth most commonly occurring cancer worldwide hampering both health and economy. Piperine had proven efficacy in fighting skin cancer cells. Unfortunately, this natural agent had limited ability to penetrate the skin.
View Article and Find Full Text PDFInt J Cardiol Heart Vasc
February 2023
Department of Internal Medicine II, University Hospital Bonn, Bonn, Germany.
Aims: Na/Ca exchanger (NCX) upregulation in cardiac diseases like heart failure promotes as an independent proarrhythmic factor early and delayed afterdepolarizations (EADs/DADs) on the single cell level. Consequently, NCX inhibition protects against EADs and DADs in isolated cardiomyocytes. We here investigate, whether these promising cellular findings likewise apply to an setup.
View Article and Find Full Text PDFJ Card Fail
November 2018
Graduate Institute of Clinical Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan; Division of Cardiovascular Medicine, Department of Internal Medicine, Wan-Fang Hospital, Taipei Medical University, Taipei, Taiwan. Electronic address:
Background: Ivabradine increases the risk of atrial fibrillation (AF). Heart failure (HF) or sinoatrial node (SAN) dysfunction increases the risk of AF, and pulmonary veins (PVs) play a critical role in the pathophysiology of AF. This study investigated the electrophysiologic effects of ivabradine on SANs and PVs in a rabbit model of HF.
View Article and Find Full Text PDFPLoS Comput Biol
November 2017
Department of Biomedical Engineering and Institute for Computational Medicine, Johns Hopkins University, Baltimore, MD, United States of America.
Ectopic heartbeats can trigger reentrant arrhythmias, leading to ventricular fibrillation and sudden cardiac death. Such events have been attributed to perturbed Ca2+ handling in cardiac myocytes leading to spontaneous Ca2+ release and delayed afterdepolarizations (DADs). However, the ways in which perturbation of specific molecular mechanisms alters the probability of ectopic beats is not understood.
View Article and Find Full Text PDFBiophys J
May 2017
Division of Cardiology, Department of Medicine, UCLA Cardiovascular Research Laboratory, University of California, Los Angeles, California; Department of Physiology, David Geffen School of Medicine, University of California, Los Angeles, California. Electronic address:
Spontaneous calcium (Ca) waves in cardiac myocytes underlie delayed afterdepolarizations (DADs) that trigger cardiac arrhythmias. How these subcellular/cellular events overcome source-sink factors in cardiac tissue to generate DADs of sufficient amplitude to trigger action potentials is not fully understood. Here, we evaluate quantitatively how factors at the subcellular scale (number of Ca wave initiation sites), cellular scale (sarcoplasmic reticulum (SR) Ca load), and tissue scale (synchrony of Ca release in populations of myocytes) determine DAD features in cardiac tissue using a combined experimental and computational modeling approach.
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