AI Article Synopsis
- Synthesis and biological testing of various amino-substituted benzenesulfonamides were conducted on Candida albicans and Candida tropicalis strains.
- The 4-amino derivatives showed more effective antimycotic activity compared to 2-amino and 3-amino derivatives, with a minimum inhibitory concentration (MIC) around 50 micrograms/ml.
- The length of the alkyl chain did not significantly impact the biological activity of the compounds, except for certain aralkyl variants, while antibacterial activity in 4-amino derivatives was found to be low against all tested bacterial strains.
Article Abstract
2-, 3- and 4-amino-N-(6-amino-1,4-dihydro-4-oxo-2-mercapto (or alkylthio)-5-pyrimidinyl)benzenesulfonamides were synthesized and biologically tested on different strains of Candida albicans and Candida tropicalis. Some of the 4-aminoderivatives were also tested for antibacterial properties on numerous bacterial strains. Antimycotic activity of 4-amino compounds, expressed as MIC, is around 50 micrograms/ml and higher than that of both 2-amino- and 3-aminoderivatives. In all these compounds alkyl chain length does not seem to have any notable effects on biological activity, an exception being made for some aralkyl compounds. Antibacterial activity of 4-aminoderivatives is very low for all strains tested.
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