AI Article Synopsis
- The study examined the changes in phospholipid levels in blood serum, liver, kidneys, and tumor tissues of rats during different stages of cancer development caused by nitrosodimethylamine.
- Key findings showed that kidney tumor tissues had distinct differences in total phospholipid content compared to normal kidney tissue, especially in specific phospholipids like cardiolipin and sphingomyelin.
- Notable changes were also observed in the phospholipid profiles of blood serum and liver, highlighting an inverse relationship between the amounts of phosphatidylethanolamine and phosphatidylserine in these tissues of tumor-bearing rats.
Article Abstract
Quantitative changes in phospholipid spectra of blood serum, liver, kidneys and tumour tissues were determined at different stages of carcinogenesis induced by nitrosodimethylamine in rats. It was established that tissue of kidney tumours differs from homologous tissue only in the total amount of phospholipids as well as of cardiolipin phosphatidylethanolamine, phosphatidylserine and sphingomyelin. Essential changes were revealed in the phospholipid spectrum of blood serum and liver of tumour-bearing rats. The inverse correlation was found in phosphatidylethanolamine and phosphatidylserine amount in these tissues.
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