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Respir Res
March 2025
Department of Respiratory and Critical Care Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, People's Republic of China.
Pulmonary hypertension (PH) is a progressive and life-threatening cardiopulmonary disease that is not uncommon. The modulation of the pulmonary artery (PA) involves various fatty acids, including omega-6 polyunsaturated fatty acids (ω-6 PUFAs) and ω-6 PUFAs-derived oxylipins. These lipid mediators are produced through cyclooxygenase (COX), lipoxygenase (LOX), cytochrome P450 (CYP450), and non-enzymatic pathways.
View Article and Find Full Text PDFJ Assoc Physicians India
March 2025
Consultant, Department of Critical Care Medicine, Apex Hospitals, Jaipur, Rajasthan, India.
Reversible cerebral vasoconstriction syndrome (RCVS) is characterized by recurrent thunderclap headache and multifocal cerebral arterial constriction, which can be associated with pregnancy and exposure to certain vasoactive agents. It is usually evoked by triggering agents in 80% of cases. RCVS can present with focal deficits or new-onset seizure in 8-43% and 1-17% of cases, respectively.
View Article and Find Full Text PDFJ Pharm Pract
March 2025
Department of Pharmacy Practice, Barry and Judy Silverman College of Pharmacy, Nova Southeastern University, Fort Lauderdale, FL, USA.
Dicyclomine is an antimuscarinic agent approved for treatment of irritable bowel syndrome-associated abdominal pain. Intravenous (IV) administration should be avoided due to potential for thrombosis, but real-world evidence is generally lacking. This case report presents a thrombotic complication associated with inadvertent IV administration of dicyclomine.
View Article and Find Full Text PDFExp Neurol
March 2025
The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Melbourne, Australia. Electronic address:
Necessary for enhanced understanding of brain injury, and for developing new therapies, is the generation of reliable animal models. While many models are available, each comes with benefits and limitations. Intracerebral injection of the vasoconstrictive peptide endothelin-1 creates one of the most widely adopted models of focal ischemic stroke in rats, yet its potency is underwhelming in mice.
View Article and Find Full Text PDFAm J Hypertens
March 2025
Department of Health and Human Physiology, The University of Iowa, Iowa City, Iowa, United States.
Background: Women with a history of preeclampsia are at increased risk of developing cardiovascular disease compared with women who had a healthy pregnancy. One potential mechanism underlying this increased risk is microvascular endothelial dysfunction, characterized by reduced nitric oxide (NO)-dependent dilation and is mediated, in part, by increased vasoconstrictor sensitivity to angiotensin II, which persists postpartum. We hypothesized that systemic angiotensin II type 1 receptor (AT1R) inhibition via once-daily oral losartan treatment would 1) improve endothelium- and NO-dependent dilation, and 2) reduce angiotensin II-mediated vasoconstriction, in the microvasculature of women with a history of preeclampsia.
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