Renal involvement is not frequently observed during therapy with clometacine and its mechanism not fully understood. We report on a case of acute renal failure occurring four times in conjunction with acute hepatitis before the causative effect of clometacine was demonstrated. Drug hypersensitivity was documented by anatomical findings consisting in renal interstitial infiltration by mononuclear cells and eosinophils and by hypereosinophilia, increase in plasma IgE and a positive basophil degranulation test.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
renal failure
8
[acute renal
4
failure caused
4
caused clometacin
4
clometacin hypersensitivity]
4
hypersensitivity] renal
4
renal involvement
4
involvement frequently
4
frequently observed
4
observed therapy
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!