We present a case of a 52-year-old white female with what we believe is the first documented example of a primary melanoma of the middle ear. Multiple myringotomies and two tube insertions over a 14-month period were carried out until frank hemorrhage was encountered on the last one. Middle ear exploration found the lesion to be a primary melanoma. The supposed course of her diseased ear is discussed as regards the lag between effusion and frank blood when tumor was finally hit on the last myringotomy.

Download full-text PDF

Source

Publication Analysis

Top Keywords

primary melanoma
12
middle ear
12
melanoma middle
8
ear
4
ear case
4
case 52-year-old
4
52-year-old white
4
white female
4
female documented
4
documented example
4

Similar Publications

Unraveling the controversy: exploring the link between sex hormones and skin cancers through a meta-analysis and systematic review.

Arch Dermatol Res

January 2025

Department of Plastic and Burn Surgery, West China Hospital, Sichuan University, No. 37, Guoxue Alley, Wuhou District, Chengdu, 610041, Sichuan Province, P. R. China.

Skin cancers continue to present unresolved challenges, particularly regarding the association with sex hormones, which remains a topic of controversy. A systematic review is currently warranted to address these issues. To analyze if sex hormones result in a higher incidence of skin cancers (cutaneous melanoma, basal cell carcinoma, squamous cell carcinoma).

View Article and Find Full Text PDF

Melanoma is an immunogenic tumor. The melanoma tumor immune microenvironment (TIME) is made up of a heterogenous mix of both immune and non-immune cells as well as a multitude of signaling molecules. The interactions between tumor cells, immune cells and signaling molecules affect tumor progression and therapeutic responses.

View Article and Find Full Text PDF

Protocatechuic aldehyde sensitizes BRAF-mutant melanoma cells to temozolomide through inducing FANCD2 degradation.

Med Oncol

January 2025

Engineering Research Center of Sichuan-Tibet Traditional Medicinal Plant, Chengdu University, Chengdu, 610106, China.

Temozolomide (TMZ)-based chemotherapy is a primary regimen for melanoma patients who have failed targeted therapy or immunotherapy. However, the low response rate of TMZ-based chemotherapy challenges the patients' prognosis. BRAF mutation is the most frequently mutated site in melanoma.

View Article and Find Full Text PDF

Introduction And Importance: Cutaneous malignant melanoma, originating from melanocytes, is a highly metastatic cancer with an incidence rate of 0.9 per 100,000. The gastrointestinal tract is a common site of metastasis, with the small intestine being particularly affected.

View Article and Find Full Text PDF

A 44-year-old man presented to the emergency department with high-risk cardiogenic syncope. Investigations revealed a cardiac mass, corresponding to metastatic melanoma. However, the primary tumor was not found.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!