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Gastrointestinal absorption and its regulation of hawthorn leaves flavonoids.
Sci Rep
January 2025
School of Pharmacy, Fudan University, 826 Zhangheng Road, Shanghai, 201203, P.R. China.
Hawthorn leave flavonoids (HLF) are widely used as an herb or dietary supplements for cardio-cerebrovascular diseases. However, its gastrointestinal absorption behavior and mechanism have not been disclosed. In this study, gastrointestinal absorption and its regulation of 4''-O-glucosylvitexin (GLV), 2''-O-rhamnosylvitexin (RHV), vitexin (VIT), rutin (RUT) and hyperoside (HP) in HLF were investigated using in vitro, in situ and in vivo models.
View Article and Find Full Text PDFImprovement and Recovery of Intestinal Flora Disorder Caused by Ciprofloxacin Using Lactic Acid Bacteria.
Probiotics Antimicrob Proteins
November 2024
College of Food Science and Engineering, Northwest A&F University, 28# Xinong Road, Yangling 712100, Xianyang, Shaanxi, China.
Article Synopsis
- Four lactic acid bacteria (LAB) strains were tested for their ability to survive harsh intestinal conditions and adhere to intestinal cells, with Lactobacillus brevis 505 showing the best performance.
- After treatment with ciprofloxacin, mice experienced some recovery in their intestinal flora naturally, but full restoration was difficult; however, intervention with L. brevis 505 resulted in significantly better recovery of intestinal health compared to natural recovery.
- L. brevis 505 not only helped improve the diversity and abundance of beneficial gut bacteria but also regulated immune factors, making it a promising probiotic for restoring gut microbiota after antibiotic treatment.
Study on the characteristics of intestinal flora in postoperative patients with gastric cancer and the nutritional therapy of microflora transplantation.
Minerva Surg
November 2024
Department of Gastroenterology, Chongming Branch, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China -
Fruits of L. have been used as Uyghur medicine due to the properties of treating spleen and stomach weakness, indigestion, enteritis, diarrhea, lung heat, and cough. However, the anti-diarrhea mechanism was still not clear.
View Article and Find Full Text PDFEffects of Weizhuan'an on rats with precancerous lesions of gastric cancer based on regulating gastric mucosal microflora and inflammatory factors.
Front Pharmacol
August 2024
Department of Nephropathy, Second Affiliated Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, China.
Objectives: This study aimed to observe the intervention of Weizhuan'an prescription on rats with precancerous lesions of gastric cancer (PLGC) as well as its regulation on gastric mucosal microflora and inflammatory factors and explore the pharmacodynamic mechanisms of Weizhuan'an Formula.
Methods: The rats were classified into the blank control group (BCG); low-, medium-, and high-dose groups of Weizhuan'an prescription (LDG, MDG, and HDG, respectively); and natural recovery group (NRG) at random. The rats in the traditional Chinese medicine (TCM) group were given corresponding doses of Weizhuan'an formula, while the rats in the NRG and BCG were given an equivalent volume of distilled water for 12 weeks.
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