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Dipyridamole Ameliorates Memory Impairment and Increases Hippocampal Calbindin Expression in Niemann Pick C1 Mice.
J Neurosci Res
December 2024
National Center for Drug Research and Evaluation, Istituto Superiore di Sanità, Rome, Italy.
Niemann Pick type C1 (NPC1) is a rare, fatal disorder characterized by endosomal lipid accumulation that leads to damage of both peripheral organs and central nervous system (cerebellum and hippocampus are especially affected). Currently, miglustat is the only approved drug for NPC1, thus the identification of new treatments is mandatory. We have previously demonstrated that the drug dipyridamole (DIP), an enhancer of adenosine signaling, can reduce the pathological phenotype in patient-derived fibroblasts.
View Article and Find Full Text PDFEfficacy and safety of edaravone combined with Ginkgo Leaf Extract and Dipyridamole in the treatment of acute cerebral infarction: A systematic review and meta-analysis.
Medicine (Baltimore)
November 2024
Department of Neurology, The Second Affiliated Hospital of Zhejiang University of Chinese Medicine, Hangzhou, Zhejiang, China.
Background: To evaluate the clinical efficacy and safety of edaravone combined with Ginkgo Leaf Extract and Dipyridamole (GLED) versus edaravone alone in the treatment of acute cerebral infarction (ACI) by the method of meta-analysis.
Methods: PubMed, Web of Science, Cochrane Library, China National Knowledge Infrastructure, WANFANG DATA, and Chinese Scientific Journal Database were searched to identify publications on edaravone combined with GLED for ACI from inception to June 20, 2024. Stata15.
Treatment of restless legs syndrome and periodic limb movement disorder: an American Academy of Sleep Medicine clinical practice guideline.
J Clin Sleep Med
January 2025
Department of Neurology, Vanderbilt University, Nashville, Tennessee.
Introduction: This guideline establishes clinical practice recommendations for treatment of restless legs syndrome (RLS) and periodic limb movement disorder (PLMD) in adults and pediatric patients.
Methods: The American Academy of Sleep Medicine (AASM) commissioned a task force of experts in sleep medicine to develop recommendations and assign strengths based on a systematic review of the literature and an assessment of the evidence using the grading of recommendations assessment, development, and evaluation methodology. The task force provided a summary of the relevant literature and the certainty of evidence, the balance of benefits and harms, patient values and preferences, and resource use considerations that support the recommendations.
Biorelevant dissolution and its concept have been widely accepted and further developed to meaningfully predict the bioperformance of oral drug products. Biorelevant methodologies have been applied to design and optimize oral formulations, to facilitate formulation bridging, and to predict the outcome of bioperformance by coupling the results with modeling. Yet, those methodologies have often been independently customized to align with specific aspects of the oral drug products being developed.
View Article and Find Full Text PDFIs there an association between glomerular hyperfiltration and coronary flow velocity reserve in patients with gestational diabetes history?
Biomol Biomed
September 2024
Department of Cardiology, Suleyman Yalcin City Hospital, Istanbul, Türkiye.
Article Synopsis
- Glomerular hyperfiltration (GHF) is identified as an early indicator of chronic kidney disease that could also signal coronary issues in women with a history of gestational diabetes (GDM).
- The study involved 166 patients with GDM, categorizing them by their glomerular filtration rate (GFR) into three groups, and measuring their coronary flow velocity reserve (CFVR) before and after a stress test using dipyridamole.
- Results indicated that women with lower GFR had the lowest CFVR, emphasizing the link between metabolic health markers (like HbA1c and HOMA-IR) and cardiovascular risks, suggesting that improving these factors may help prevent heart disease.
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