Five patients with melanoacanthoma are reported. The skin lesions consisted of a single, round plaque measuring several centimeters in diameter. Histologic findings were characterized by formation within an acanthotic epidermis, of many islands of small basaloid cells and highly dendritic melanocytes. Electron microscopic examination of one lesion revealed a disturbance of melanin transfer from the highly dendritic melanocytes to the neighboring keratinocytes.
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http://dx.doi.org/10.1111/j.1600-0560.1984.tb00383.x | DOI Listing |
Nanomaterials (Basel)
December 2024
Institute for Energy and Materials Processes-Reactive Fluids, University of Duisburg-Essen, 47057 Duisburg, Germany.
Solid-state electrolytes for lithium-ion batteries, which enable a significant increase in storage capacity, are at the forefront of alternative energy storage systems due to their attractive properties such as wide electrochemical stability window, relatively superior contact stability against Li metal, inherently dendrite inhibition, and a wide range of temperature functionality. NASICON-type solid electrolytes are an exciting candidate within ceramic electrolytes due to their high ionic conductivity and low moisture sensitivity, making them a prime candidate for pure oxidic and hybrid ceramic-in-polymer composite electrolytes. Here, we report on producing pure and Y-doped Lithium Aluminum Titanium Phosphate (LATP) nanoparticles by spray-flame synthesis.
View Article and Find Full Text PDFDrug Deliv Transl Res
January 2025
Department of Biomedical Engineering and Environmental Sciences, National Tsing Hua University, 300044, Hsinchu, Taiwan.
Glioblastoma (GBM), a highly aggressive brain tumor, poses significant treatment challenges due to its highly immunosuppressive microenvironment and the brain immune privilege. Immunotherapy activating the immune system and T lymphocyte infiltration holds great promise against GBM. However, the brain's low immunogenicity and the difficulty of crossing the blood-brain barrier (BBB) hinder therapeutic efficacy.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Background: Aging and the decline in sex steroid hormone (e.g., estrogen) are associated with a potential loss of its neuroprotective effects on the female brain.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
Wisconsin Alzheimer's Disease Research Center, University of Wisconsin-Madison, School of Medicine and Public Health, Madison, WI, USA.
Background: Residence in highly socioeconomically disadvantaged neighborhoods has recently been associated with Alzheimer's disease (AD) neuropathology at autopsy, cognitive decline, and magnetic resonance imaging (MRI) markers of volumetric brain atrophy in cognitively unimpaired adults. Furthermore, there is mounting evidence that markers of brain microstructure derived from diffusion-weighted MRI (DWI), including neurite density index (NDI), orientation dispersion index (ODI), and isotropic volume fraction (ISO), are sensitive to AD-related neurodegeneration. In this study, we used linear mixed-effects (LME) modeling to investigate the hypothesis that neighborhood-level disadvantage is associated with mixed-longitudinal trajectories of microstructural neurodegeneration in 539 late-middle-aged participants across the AD continuum.
View Article and Find Full Text PDFBackground: The increased incidence of Alzheimer's disease (AD) rate represent an unmet medical need and thus critical for the development of novel molecular therapeutics. Recent work focusing on patients with apoE4 alleles has highlighted the association of brain cholesterol dysregulation with elevated pathological burden and neurodegeneration. These studies have highlighted the importance of the nuclear receptor Liver X receptor (LXR) for developing AD therapies.
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