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Treatment-related acute toxicity with adjuvant systemic treatment among patients with HER2-positive early invasive breast cancer: a national population-based cohort study.
BMJ Oncol
September 2023
Department of Health Services Research & Policy, London School of Hygiene & Tropical Medicine, London, UK.
Objective: Although adjuvant trastuzumab-based treatment (TBT) improves survival for patients with HER2-positive early invasive breast cancer (EIBC), risk of toxicity grows as patient age increases. We examined use of TBT and associated severe acute toxicity event (SATE) rates to understand the real-world impact.
Methods And Analysis: Women (50+ years), newly diagnosed with HER2-positive EIBC in England, 2014-2019, were identified from Cancer Registry data, linked to the Systemic Anti-Cancer Therapy dataset for TBT information.
Pregnancy-associated systemic lupus erythematosus in people living with HIV/AIDS.
Indian J Sex Transm Dis AIDS
October 2024
Department of Dermatology, Lady Hardinge Medical College, New Delhi, India.
Pregnancy with systemic lupus erythematosus (SLE) requires special attention in view of the enhanced risks to the fetus and the aggravation of SLE during pregnancy. Human immunodeficiency virus infection can further complicate the course of pregnancy as well as the outcome. We present a case of a 28-year-old primigravida who was diagnosed case of people living with HIV/AIDS and presented with SLE at 34 weeks of gestation.
View Article and Find Full Text PDFPerinatal psychiatric emergencies in rural Australia: In urgent need of attention.
Aust N Z J Psychiatry
February 2025
Telethon Kids Institute, Perth, WA, Australia.
Objectives: The burden of perinatal mental illness is a significant global concern, affecting approximately 10-20% of women at this stage of life. It is well recognised that Rural Australia has far less health services and mental health specialists per capita than metropolitan regions. While women have more babies in rural settings, their access to maternal health care is conversely limited or absent.
View Article and Find Full Text PDFIncidence and predictors of adverse birth outcomes among women who gave birth at Assosa general hospital, Northwest Ethiopia: a retrospective cohort study.
BMC Pregnancy Childbirth
January 2025
Department of Public Health, College of Health Science, Assosa University, Benishangul-Gumuz region, Assosa Town, Ethiopia.
Background: Adverse birth outcomes are a significant public health problem worldwide, particularly in low- and middle-income countries. Adverse birth outcomes have significant immediate and long-term health consequences for infants and their families. Understanding the determinants of adverse birth outcomes is crucial to effective interventions.
View Article and Find Full Text PDFImpact of maternal age on birth weight-related adverse outcomes in newborns: a retrospective study in south-central China.
BMC Pregnancy Childbirth
January 2025
Department of Child Healthcare, Changsha City Maternal and Child Health Care Hospital, Chengnan East Road No.416, Yuhua District, Changsha, 410007, China.
Background: Birth weight is a critical indicator for assessing fetal development and newborn health status. This study aimed to examine both linear and nonlinear associations between maternal age and birth weight and their related adverse outcomes.
Methods: 15,923 delivery data from 2018 to 2021 for pregnant women from the Changsha Maternal and Child Health Care Hospital were reviewed by a retrospective study.
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