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How Often Is Rifampin Therapy Initiated and Completed in Patients With Periprosthetic Joint Infections?
Clin Orthop Relat Res
January 2025
Department of Medicine, Duke University, Durham, NC, USA.
Background: Rifampin therapy is indicated for the treatment of staphylococcal periprosthetic joint infection (PJI) in patients who have undergone debridement, antibiotics, and implant retention (DAIR) or one-stage revision as per the Infectious Diseases Society of America (IDSA) guideline. Given the well-established effectiveness of rifampin as adjunctive therapy in staphylococcal PJI, it is crucial to evaluate its utilization in practice and identify factors that contribute to its underuse or incomplete administration, as these deviations may undermine treatment efficacy and patient outcomes.
Questions/purposes: Among patients who met clear indications for rifampin use having undergone DAIR or one-stage revision for staphylococcal PJI, (1) what proportion of patients did not receive it? (2) What proportion of patients started it but did not complete the planned course? (3) Where documented in the medical record, what were the common reasons for not using it or prematurely discontinuing it, and in what percentage of the patients' charts was no reason given? (4) What proportion of patients were taking a medication that put them at risk for a drug-drug interaction (DDI)?
Methods: Using an institutional database, patients who underwent DAIR or revision arthroplasty for PJI from January 2013 to April 2023 were identified (n = 935).
[Coronary Angiography in Clinical Practice: Update on Indications, Complications, and Contraindications].
Rev Med Chil
November 2024
Departamento de Cardiología, Instituto Nacional del Tórax, Santiago, Chile.
Unlabelled: Coronary angiography (CA) is the gold standard for identifying the presence and extent of atherosclerotic coronary artery disease or dynamic stenosis of the arteries.
Aim: Review of the literature and international clinical guidelines on the evidence of its indications in different clinical scenarios.
Method: Qualitative study through a narrative review of the current indications of the technique, limitations, possible complications and contraindications.
Clear Aligner Treatment: Indications, Advantages, and Adverse Effects-A Systematic Review.
Dent J (Basel)
January 2025
Section of Orthodontics, Department of Odontology, Faculty of Health and Medical Sciences, University of Copenhagen, DK-2200 Copenhagen, Denmark.
: Clear aligner treatment (CAT) has gained interest among clinicians as well as among patients. The aim of the present study was to systematically review the literature regarding current viewpoints on indications, contraindications, advantages, disadvantages, and adverse effects in CAT. : A search was performed in the PubMed and Embase databases, yielding 18 studies eligible for inclusion.
View Article and Find Full Text PDF[Transcutaneous osseointegrated prostheses systems (TOPS) for rehabilitation following limb loss : Surgical approach for necessary removal of the implant].
Oper Orthop Traumatol
January 2025
Klinik für Unfall‑, Hand- und Wiederherstellungschirurgie, Universitätsmedizin Rostock, Schillingallee 35, 18057, Rostock, Deutschland.
Objective: Removal of a transcutaneous osseintegrated endo-fix stem (ESKA Orthopaedic, Lübeck, Germany) following a fatigue fracture of the implant, whilst protecting the residual femur bone to allow transcutaneous osseointegrated prosthesis system (TOPS) reimplantation.
Indications: A patient's request for a further TOPS implantation following a fatigue fracture of a circular osseointegrated implant stem.
Contraindications: Impending destruction of the bone tube through mobilisation of the femoral implant stem with insufficient thickness of the cortical wall (< 2-3 mm).
[Modified Z-plasty of the patellar tendon for patella baja and flexion deficits].
Oper Orthop Traumatol
January 2025
Klinik für Orthopädie und Unfallchirurgie, Martin-Luther-Krankenhaus Berlin, Caspar-Theyss-Str. 27-33, 14193, Berlin, Deutschland.
Objective: Lengthening of the patellar tendon to normalize patellar height and improve knee flexion deficits.
Indications: Flexion deficits in combination with patella baja (Caton index < 0.6).
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