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Melatonin lessens the susceptibility to atrial fibrillation in sleep deprivation by ameliorating Ca mishandling in response to mitochondrial oxidative stress.
Int Immunopharmacol
January 2025
Xinjiang Key Laboratory of Cardiac Electrophysiology and Remodeling, The First Affiliated Hospital of Xinjiang Medical University, Urumqi 830011, China; Department of Pacing and Electrophysiology, The First Affiliated Hospital of Xinjiang Medical University, Urumqi 830011, China. Electronic address:
Background: The antiarrhythmic effect of melatonin(MLT) has been demonstrated in several studies; however, this hypothesis has recently been contested. Our research seeks to determine if exogenous MLT supplementation can reduce atrial fibrillation (AF) susceptibility due to sleep deprivation (SD) by addressing Ca mishandling and atrial mitochondrial oxidative stress.
Methods: Adult rats received daily MLT or vehicle injections and were exposed to a modified water tank.
Dual calcium-voltage optical mapping of regional voltage and calcium signals in intact murine -R2474S hearts.
J Mol Cell Cardiol Plus
December 2024
Key Laboratory of Medical Electrophysiology of the Ministry of Education, Medical Electrophysiological Key Laboratory of Sichuan Province, Institute of Cardiovascular Research, Southwest Medical University, Luzhou, Sichuan 646000, China.
Unlabelled: Abnormal regional variations in electrical and calcium homeostasis properties have been implicated in catecholaminergic polymorphic ventricular tachycardias (CPVT) attributable to abnormal RyR2-mediated store Ca release, but their underlying mechanism have not been well explored in intact hearts.
Methods: We performed in vivo and ex vivo studies including high throughput mapping of Ca transients (CaT) and transmembrane voltage (V) in murine wild-type (WT) and heterozygous -R2474S/+ hearts, before and during isoprenaline (ISO) challenge.
Results: ISO-challenged -R2474S/+ showed increased incidence of arrhythmia accompanied by abnormal Ca transients compared to WT.
Effects and mechanisms of dexmedetomidine preconditioning on isoproterenol-induced ventricular arrhythmias.
Sci Rep
November 2024
Department of Anesthesiology, Ya 'an People's Hospital, Ya 'an, 625000, Sichuan, China.
Article Synopsis
- - Dexmedetomidine (DEX) is known for its sedative and anti-anxiety properties, and it shows promise in preventing and treating arrhythmias during surgery, although its exact mechanisms are still not fully understood.
- - In experiments with mice, DEX was found to reduce the occurrence of ventricular arrhythmias induced by a stressor (isoproterenol or ISO) by stabilizing key cardiac electrical properties like action potential duration and calcium transient duration.
- - DEX pretreatment improved cardiac conduction and decreased variability in calcium signaling, indicating that it helps maintain calcium homeostasis and could be beneficial in preventing stress-induced heart issues.
Kinematic signature of high risk labored breathing revealed by novel signal analysis.
Sci Rep
November 2024
Department of Medicine, University of Virginia, Charlottesville, USA.
Breathing patterns (respiratory kinematics) contain vital prognostic information. This dimension of physiology is not captured by conventional vital signs. We sought to determine the feasibility and utility of quantifying respiratory kinematics.
View Article and Find Full Text PDFBrain-to-heart cholinergic synapse-calcium signaling mediates ischemic stroke-induced atrial fibrillation.
Theranostics
October 2024
State Key Laboratory of Component-based Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Beihua South Road, JingHai District, Tianjin 301617, China.
Stroke-related cardiovascular diseases have attracted considerable attention, with atrial fibrillation (AF) being among the most frequent complications. Despite increasing clinical evidence, experimental models of stroke-induced AF are still lacking, hindering mechanistic discoveries and the development of adequate therapeutics targeting this stroke-heart syndrome (SHS). This study aims to create a rat model of ischemic stroke-induced AF (ISIAF) and to explore the efficacy and mechanism of Wenxin Keli (WK), an antiarrhythmic Chinese medicine.
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