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Nerve-Derived Extracellular Matrix Promotes Neural Differentiation of Bone Marrow Stromal Cells and Enhances Interleukin-4 Efficacy for Advanced Nerve Regeneration.
Adv Healthc Mater
January 2025
Department of Orthopedic Surgery, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Zhejiang, 325000, P. R. China.
Facilitating neuronal differentiation of stem cells and microenvironment remodeling are the key challenges in cell-based transplantation strategies for central nervous system regeneration. Herein, the study harnesses the intrinsic pro-neural differentiation potential of nerve-derived extracellular matrix (NDEM) and its specific affinity for cytokines to develop an NDEM-gelatin methacryloyl(gelMA)-based bifunctional hydrogel delivery system for stem cells and cytokines. This system promotes the neural differentiation of bone marrow stromal cells (BMSCs) and optimizes the therapeutic index of Interleukin-4 (IL-4) for spinal cord injury (SCI) treatment.
View Article and Find Full Text PDFRole of Novel Chlorella vulgaris SSAU8 in Improving the Soil Health Under Induced Drought Stress.
Curr Microbiol
January 2025
Centre of Biotechnology, University of Allahabad, Prayagraj, Uttar Pradesh, 211002, India.
The severe climate change has caused a drastic water level disparity around the globe, which eventually has been one of the biggest problems of this era related to land degradation. This has caused the multidimensional impact on ecology, the environment, and their components. Algae, one of the ancient micro-engineers, are involved in the functioning of soil microcosm.
View Article and Find Full Text PDFElaborate Designed Three-Dimensional Hierarchical Conductive MOF/LDH/CF Nanoarchitectures for Superior Capacitive Deionization.
Angew Chem Int Ed Engl
January 2025
Fujian University of Technology, College of Ecological Environment and Urban Construction, 69, Xuefu South Road, Fuzhou 350118, China, 350118, Fuzhou, CHINA.
Rational exploration of cost-effective, durable, and high-performance electrode materials is imperative for advancing the progress of capacitive deionization (CDI). The integration of multicomponent layered double hydroxides (LDHs) with conjugated conductive metal-organic frameworks (c-MOFs) to fabricate bifunctional heterostructure electrode materials is considered a promising strategy. Herein, the fabrication of hierarchical conductive MOF/LDH/CF nanoarchitectures (M-CAT/LDH/CF) as CDI anodes via a controllable grafted-growth strategy is reported.
View Article and Find Full Text PDFIntegrating network pharmacology with molecular docking and dynamics to uncover therapeutic targets and signaling mechanisms of vitamin D3 in Parkinson's disease.
Mol Divers
January 2025
School of Medicine, Zhejiang University, Hangzhou, 310000, Zhejiang, People's Republic of China.
Parkinson's disease (PD) is a chronic neurodegenerative disorder marked by dopaminergic neuron degeneration in the substantia nigra. Emerging evidence suggests vitamin D3 (VD) plays a therapeutic role in PD, but its precise molecular mechanisms remain unclear. This study employed network pharmacology and bioinformatics to identify VD's hub targets and related pathways.
View Article and Find Full Text PDFDifferentiating the contributions of Na/K pump current and persistent Na current in simulated voltage-clamp experiments.
J Neurophysiol
January 2025
Center for Integrative Brain Research, Seattle Children's Research Institute, Seattle, Washington.
The persistent Na current (I) is thought to play important roles in many brain regions including the generation of inspiration in the ventral respiratory column (VRC) of mammals. The characterization of the slow inactivation of I requires long-lasting voltage steps (>1 s), which will increase intracellular Na and activate the Na/K-ATPase pump current (I). Thus, I may contribute to the previously measured slow inactivation of I and the generation of the inspiratory bursting rhythm.
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