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Effects of dietary supplementation of myristic acid on jejunal mucosa-associated microbiota, mucosal immunity, and growth performance of nursery pigs.
Anim Sci J
January 2025
Department of Animal Science, North Carolina State University, Raleigh, NC, USA.
The objective of this study was to investigate the effects of myristic acid on jejunal mucosal microbiota, mucosal immunity, and growth performance of nursery pigs. Thirty-six pigs (6.6 ± 0.
View Article and Find Full Text PDFEffects of isoquinoline alkaloids as an alternative to antibiotic on oxidative stress, inflammatory status, and cecal microbiome of broilers under high stocking density.
Poult Sci
December 2024
Department of Animal Science, Faculty of Agriculture at Kamphaeng Saen, Kasetsart University, Kamphaeng Saen Campus, Nakhon Pathom 73140, Thailand. Electronic address:
This study investigated the effect of isoquinoline alkaloids as an alternative to bacitracin on growth performance, oxidative stress, inflammatory status, and ceca microbiome of broilers raised under high stocking density (HSD). A total of 1,500 one-day-old male Ross 308 chicks were randomly assigned to five treatment groups, with 10 replicate pens per group and 30 birds per pen, for 37 days. The treatments included normal stocking density (NSD, 10 birds/m²), HSD (15 birds/m²), HSD with 50 ppm Bacitracin (BCT50), HSD with 80 ppm isoquinoline alkaloids (IQA80), and HSD with 100 ppm isoquinoline alkaloids (IQA100).
View Article and Find Full Text PDFStructures and mechanism of condensation in nonribosomal peptide synthesis.
Nature
December 2024
Department of Biochemistry and Centre de recherche en biologie structurale, McGill University, Montréal, QC, Canada.
Article Synopsis
- * A critical aspect of NRPS function is the formation of amide bonds between amino acids, a process that has not been fully understood due to its complex nature and the mobile structure of the enzymes involved.
- * Recent research produced a modified NRPS protein, revealing detailed structures that suggest a concerted reaction mechanism, where a key histidine residue stabilizes the reaction instead of acting as a typical general base.
Metagenomic analysis reveals houseflies as indicators for monitoring environmental antibiotic resistance genes.
Environ Microbiol Rep
December 2024
State Key Laboratory of Microbial Metabolism and School of Life Sciences & Biotechnology, Shanghai Jiao Tong University, Shanghai, People's Republic of China.
Given the threat to public health posed by antibiotic resistance transmission, environmental monitoring is essential for tracking antibiotic resistance genes (ARGs). Houseflies, being ubiquitous organisms capable of carrying and disseminating ARGs, serve as suitable indicators for environmental monitoring. In this study, we employ metagenomic approaches to investigate housefly body surface samples from five typical sites associated with human activities.
View Article and Find Full Text PDFMelanin Hydrogel Inverse Opal Microneedle Patches for Wound Healing.
Small
January 2025
Department of Rheumatology and Immunology, Nanjing Drum Tower Hospital, School of Biological Science and Medical Engineering, Southeast University, Nanjing, 210096, China.
Bacterial infected wounds bring an economic burden to the worldwide medical care field. A variety of bioactives-integrated hydrogel patches are developed in response to this challenge. Here, the melanin hydrogel inverse opal microneedle patches (MNs) with antioxidant and visual color sensing abilities for the management of bacterial infected wounds are proposed.
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