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Tunable ion-release biodegradable nanoparticles enhanced pyroptosis for tumor immunotherapy.
Biomaterials
January 2025
State Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou, 350002, China. Electronic address:
Pyroptosis is an effective strategy for inducing inflammatory responses in 'cold' tumors, boosting the efficacy of immunotherapy. Although biodegradable inorganic nanoparticles (BINPs) show great potential in pyroptosis by releasing ions to break intracellular homeostasis, the limited intracellular ion release efficiency restricts pyroptosis level and subsequent immune activation. Herein, by heterovalent substitution strategy, a series of NaZrF:x%Yb (NZF:x%Yb, x = 0, 9, and 18) BINPs with tunable intracellular ion release efficiency are synthesized for enhanced pyroptosis and tumor immunotherapy.
View Article and Find Full Text PDFThe Effects of Artificial vs. Natural Rearing on Growth Performance, Thyroid Hormone Levels, Locomotor Activity, Carcass Traits and Meat Quality Characteristics in Chios Lambs.
Animals (Basel)
December 2024
Laboratory of Animal Husbandry, Department of Animal Production, Faculty of Agriculture, Forestry and Natural Environment, School of Agriculture, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece.
Artificial rearing (AR) of lambs is nowadays a common practice in Mediterranean dairy sheep production systems to enhance the milk available for cheese or yoghurt manufacturing. The sufficient growth of lambs in an AR system is vital for the economic success of dairy sheep farms. However, AR is often associated with negative impacts on the performance and physiology of lambs.
View Article and Find Full Text PDFA simple and efficient "cell in situ collagen zymography" technique to evaluate cellular collagenase activities in thyroid cancer cell lines.
Mol Biol Rep
December 2024
Department of Medical Biochemistry, School of Medicine, Dokuz Eylul University, Izmir, 35340, Türkiye.
Article Synopsis
- Collagenases, a type of matrix metalloproteinase, are key in cancer invasion and metastasis, but traditional analysis methods struggle with accurately measuring their activity in vitro.
- Researchers developed a new technique called "cell in situ collagen zymography" to improve the study of local collagenase activities, using various human thyroid cancer cell lines.
- The optimized technique demonstrated that a "sandwich model" with specific dye-quenched collagen and fixation methods effectively visualizes collagenase activity, and it proved to be applicable across different thyroid cell lines, offering a fast and affordable approach for analysis.
Thyroid response to blocking sympathetic activity in chronic cold exposed hunters in East Greenland: a case-control study.
Eur Thyroid J
December 2024
S Andersen, Department of Clinical Medicine, Aalborg University, Aalborg, Denmark.
Background: Thyroid hormones and sympathetic stimulation are needed for activating Brown adipose tissue (BAT) during cold exposure. Studies of human cold exposure have demonstrated both increased production and raised clearance of triiodothyronine (T3). Greenlandic hunters provide a unique model for evaluating metabolic effects of cold exposure.
View Article and Find Full Text PDFEnhanced interpretable thyroid disease diagnosis by leveraging synthetic oversampling and machine learning models.
BMC Med Inform Decis Mak
November 2024
Department of Information and Communication Engineering, Yeungnam University, Gyeongsan, 38541, Republic of Korea.
Thyroid illness encompasses a range of disorders affecting the thyroid gland, leading to either hyperthyroidism or hypothyroidism, which can significantly impact metabolism and overall health. Hypothyroidism can cause a slowdown in bodily processes, leading to symptoms such as fatigue, weight gain, depression, and cold sensitivity. Hyperthyroidism can lead to increased metabolism, causing symptoms like rapid weight loss, anxiety, irritability, and heart palpitations.
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