The authors subjected to a multiprofile analysis the psychomotor development and clinical status of 213 children in the third year of life in whom signs had been observed during their neonatal period of life suggesting brain injury. The control group included 206 children matched for age without any history of neonatal pathology. The investigations demonstrated statistically significantly more frequent occurrence of psychomotor development retardation or abnormalities in the neurological status in children from the studied group as compared with control children. Comparative investigations carried out at the age of 12, 24 and 36 months showed a gradual decrease of the indices suggesting psychomotor retardation or disturbances in central nervous system function.
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Eur Thyroid J
January 2025
H Heuer, Department of Endocrinology, Diabetes and Metabolism, University of Duisburg-Essen, Essen, Germany.
Objective: Mutations in the thyroid hormone (TH) transporter monocarboxylate transporter 8 (MCT8) cause Allan-Herndon-Dudley syndrome (AHDS), a severe form of psychomotor retardation with muscle hypoplasia and spastic paraplegia as key symptoms. These abnormalities have been attributed to an impaired TH transport across brain barriers and into neural cells thereby affecting brain development and function. Likewise, Mct8/Oatp1c1 (organic anion transporting polypeptide 1c1) double knockout (M/Odko) mice, a well-established murine AHDS model, display a strongly reduced TH passage into the brain as well as locomotor abnormalities.
View Article and Find Full Text PDFRecent calls for Doctor of Physical Therapy (DPT) education to cultivate the affective domain or "habits of the heart" have highlighted a gap in curricula, where cognitive and psychomotor learning domains are often the focus. Balint groups, traditionally used in medical education, offer a potential method for addressing this gap. These small peer discussion groups provide a space for students to reflect on the emotional and interpersonal complexities of providing patient care through practicing perspective-taking.
View Article and Find Full Text PDFJMIR Form Res
January 2025
School of Occupational Therapy, College of Medicine, National Taiwan University, Taipei, Taiwan.
Background: Origami is a popular activity among preschool children and can be used by therapists as an evaluation tool to assess children's development in clinical settings. It is easy to implement, appealing to children, and time-efficient, requiring only simple materials-pieces of paper. Furthermore, the products of origami may reflect children's ages and their visual-motor integration (VMI) development.
View Article and Find Full Text PDFNaunyn Schmiedebergs Arch Pharmacol
January 2025
Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research (NIPER), S.A.S. Nagar, Punjab, India.
Neuropathic pain, a challenging condition often associated with diabetes, trauma, or chemotherapy, impairs patients' quality of life. Current treatments often provide inconsistent relief and notable adverse effects, highlighting the urgent need for safer and more effective alternatives. This review investigates marine-derived bioactive compounds as potential novel therapies for neuropathic pain management.
View Article and Find Full Text PDFEur J Dent Educ
January 2025
Faculty of Medicine and Dentistry, School of Dentistry, University of Alberta, Edmonton, Alberta, Canada.
Introduction: Evidence on the pre-clinical and clinical performance of internationally trained dental students compared with domestic students and competency standards is limited. The aim of this study was to compare, relatively and normatively, the psychomotor skills of domestic and internationally trained dental students who participated in the same pre-clinical, 9-week, fixed prosthodontics course.
Materials And Methods: Course grades were collected for a total of 224 domestic and 66 internationally trained dental students between 2014 and 2020.
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