What happens to heavy-drinking and problem-drinking rates when per-capita alcohol sales (apparent consumption) increase and decrease is examined. A panel of individuals were interviewed at three 6-month intervals: winter of 1979, summer of 1979 and winter of 1980. Respondents were questioned about their drinking-related behavior in the 30 days prior to each interview. Although per-capita alcohol sales increased from winter to summer and decreased from summer to winter, heavy-drinking and problem-drinking rates changed relatively little, usually in the opposite direction of the sales change. Few of the new problem drinkers appearing from season to season also became new heavy drinkers. These findings were interpreted to mean that the Single Distribution model, relying exclusively on restricting sales to prevent alcohol misuse, is underspecified. There is much to be learned about how aggregate sales changes come about and how sales changes interact with other factors to affect problem-drinking rates.
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http://dx.doi.org/10.15288/jsa.1984.45.363 | DOI Listing |
Objective: Our objective of this study was to analyse all oncological clinical trials using regorafenib to create a complete risk/benefit profile for the drug.
Background: Creating a novel chemotherapy is costly both in time and capital spent for drug manufacturers. To regenerate what they've spent, drug manufacturers may attempt to repurpose their medications for new indications via clinical trials.
Proximal humeral fractures (PHF), ranking as the third most common osteoporotic fractures, pose a significant challenge in management. With a rising incidence in an aging population, controversy surrounds surgical versus nonoperative treatments, particularly for displaced 3- and 4-part fractures in older patients. Locking plates (LP) and proximal intramedullary nails (PHN) are primary choices for surgical intervention, but both methods entail complications.
View Article and Find Full Text PDFBr J Pharmacol
January 2025
Department of Pharmacology, The University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA.
Background And Purpose: The use of 'bath salts' drug preparations has been associated with high rates of toxicity and death. Preparations often contain mixtures of drugs, including multiple synthetic cathinones or synthetic cathinones and caffeine. Little is known about the interactions of 'bath salts' constituents and adverse effects often reported by users.
View Article and Find Full Text PDFBMC Neurol
January 2025
Department of Neurosciences, College of Medicine and Philippine General Hospital, University of the Philippines Manila, Manila, Philippines.
Background: Guillain-Barré syndrome (GBS) presents with progressive ascending weakness, but it can also present with dysautonomia such as tachycardia, blood pressure fluctuations, diaphoresis, ileus, and urinary retention. GBS patients with dysautonomia was observed to have longer hospital stays and higher mortality rates than those without dysautonomia. We aimed to determine the risk factors for dysautonomia and its manifestations among patients with GBS and compared their features to those without dysautonomia.
View Article and Find Full Text PDFDigestion
January 2025
Department of Gastroenterology, First Hospital of Yangtze University, Jingzhou, China.
Background: Alcoholic pancreatitis is a progressive condition characterized by susceptibility to recurrence, progression to chronic pancreatitis, complications, and high morbidity.
Summary: The main causes include long-term alcoholism, excessive drinking, the toxic effects of alcohol metabolites, interactions with biliary diseases, and genetic factors. Alcohol is the second leading cause of acute pancreatitis (AP) in the USA, accounting for one-third of all AP cases.
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