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Weighing up GnRH agonist therapy for endometriosis: outcomes and the treatment paradigm.
Expert Opin Pharmacother
January 2025
Obstetrics and Gynecology Department Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, MG, Brazil.
Introduction: Endometriosis is a chronic inflammatory estrogen-dependent disease affecting 10% of women worldwide leading to chronic pelvic pain and infertility which may be treated clinically or surgically.
Areas Covered: Current literaure was reviewed using the keywords 'gonadotropin releasing hormone agonists (GnRHa),' 'endometriosis,' 'infertility' and 'chronic pelvic pain.' Relevant papers prioritizing randomized controlled clinical trials (RCT), systematic reviews, meta-analyses, as well as international guidelines were evaluated.
Enhancing Radiation Therapy Response in Prostate Cancer Through Metabolic Modulation by Mito-Lonidamine: A H and P Magnetic Resonance Spectroscopy Study.
Int J Mol Sci
January 2025
Department of Radiology, University of Pennsylvania, Philadelphia, PA 19104, USA.
Radiation therapy (RT) is the cornerstone treatment for prostate cancer; however, it frequently induces gastrointestinal and genitourinary toxicities that substantially diminish the patients' quality of life. While many individuals experience transient side effects, a subset endures persistent, long-term complications. A promising strategy to mitigate these toxicities involves enhancing tumor radiosensitivity, potentially allowing for lower radiation doses.
View Article and Find Full Text PDFTissue bioaccumulation and distribution of organic contaminants in Brazilian guitarfish Pseudobatos horkelii reveal a concerning impact of contraceptive hormones and fecal sterols.
Mar Pollut Bull
January 2025
Instituto de Ciências Biológicas, Universidade Federal do Rio Grande - FURG, Rio Grande, RS, Brazil. Electronic address:
The critically endangered Brazilian guitarfish faces significant threats from environmental contamination. Assessing the impacts of such stressor is paramount from a conservational perspective. This study investigated the concentrations, distribution and accumulation patterns of organic contaminants in pregnant Brazilian guitarfish Pseudobatos horkelii.
View Article and Find Full Text PDFRemoval of an incarcerated intrauterine device reaching the serosal surface of the uterus by hysteroscopy alone: a case report.
Front Med (Lausanne)
January 2025
Department of Gynecology and Obstetrics, International Peace Maternity and Child Health Hospital Shanghai Jiao Tong University School of Medicine, Shanghai Key Laboratory of Embryo Original Diseases, Shanghai Municipal Key Clinical Specialty, Shanghai, China.
Background: An intrauterine device (IUD) is a widely used long-term contraceptive device for family planning. However, the IUD can lead to various complications. Severe complications and remedial measures caused by IUDs have been reported in the literature; however, detailed surgical approaches for safely removing the IUD within the minimum surgical range have rarely been described especially in postmenopausal women.
View Article and Find Full Text PDFFactors associated with menstrual-related disturbances following SARS-CoV-2 vaccination: a Spanish retrospective observational study in formerly menstruating women.
Women Health
January 2025
Neuroimmunophysiology and Chrononutrition Research Group, Department of Physiology, Universidad de Extremadura, Badajoz, Spain.
Background: A growing body of evidence suggests a potential link between the SARS-CoV-2 vaccine and menstrual changes in women who were menstruating at the time of vaccination. Nevertheless, the prevalence of this event in those with secondary amenorrhea for different causes, i.e.
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