A new principle of retinoscopy proposes that the endpoint of neutralization be placed at infinity rather than into the aperture of the retinoscope. The advantages of the method are (1) the pupillary reflex is sharply defined and enhanced at neutralization, (2) the pupillary reflex width is equal to the diameter of the smallest aperture of the observation system, (3) the relative speed of the pupillary reflex is equal to 1, that is, the speed of the reflex is that of the scanning speed, and (4) neutralization at infinity is independent of the observation distance. The lens used gives the "net" retinoscopy.
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http://dx.doi.org/10.1001/archopht.1984.01040031138042 | DOI Listing |
CNS Neurosci Ther
November 2024
Department of Neurology, Huashan Hospital, Fudan University and Institute of Neurology, Fudan University, Shanghai, China.
J Clin Pharmacol
October 2024
Division of Rheumatology, Department of Medicine III, Medical University of Vienna, Vienna, Austria.
CT-P47 is a candidate biosimilar of tocilizumab. This 12-week, randomized, double-blind, parallel-design, phase 1 study aimed to demonstrate pharmacokinetic (PK) equivalence of CT-P47 and reference tocilizumab. Participants were healthy Japanese adults aged 18-55 years.
View Article and Find Full Text PDFClin Transl Sci
October 2024
Clinical Trials Center, Chungnam National University Hospital, Daejeon, Korea.
J Infect
November 2024
Infectious Diseases Division, Department of Diagnostics and Public Health, University of Verona, Verona, Italy.
Background: The clinical effectiveness of early therapies for mild-to-moderate COVID-19, comparing antivirals and monoclonal antibodies (mAbs) during the Omicron era, has not been conclusively assessed through a post-approval comparative trial. We present a pooled analysis of two randomized clinical trials conducted during Omicron waves.
Methods: The MANTICO2/MONET trial is a pooled analysis of two multicentric, independent, phase-4, three-arm, superiority, randomized, open-label trials.
Clin Pharmacol Drug Dev
December 2024
SocraMetrics GmbH, Erfurt, Germany.
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