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Interferon regulatory factor 2 of red-spotted grouper (Epinephelus akaara): insights into its transcriptional profiling, antiviral potential, and function in macrophage polarization.
Dev Comp Immunol
January 2025
Department of Marine Life Sciences & Center for Genomic Selection in Korean Aquaculture, Jeju National University, Jeju 63243, Republic of Korea; Marine Life Research Institute, Jeju National University, Jeju 63333, Republic of Korea. Electronic address:
Interferon regulatory factor 2 (IRF2) is a member of the IRF family that is specifically involved in diverse immune responses via interferon (IFN)/IRF-dependent signaling pathways. In this study, IRF2 of Epinephelus akaara (EAIRF2) was identified and characterized by evaluating its structural and functional properties. EAIRF2 showed the highest homology with IRF2 of Epinephelus coioides and clustered with teleosts in the phylogenetic tree.
View Article and Find Full Text PDFTitanium Dioxide (TiO) Incorporation into Poly(ether sulfone) (PES) Hollow Fiber Membranes (HFMs) Improves Biocompatibility and Separation Performance for Bioartificial Kidney (BAK) and Hemodialysis Applications.
ACS Appl Bio Mater
January 2025
Department of Chemical Engineering, Indian Institute of Technology Bombay, Mumbai 400076, India.
Hemodialysis and bioartificial kidney (BAK), which mimic both physical and biological functions, can significantly impact chronic kidney disease (CKD) patients. Here we report on Hollow fiber membranes (HFMs) with enhanced separation of uremic toxins along with enhanced hemocompatibility and biocompatibility that also promote the growth of kidney cells. The improvement arises from the addition of titanium dioxide (0.
View Article and Find Full Text PDFFacile fabrication of biocompatible carbon dots from egg white by one-step neutralization heat reaction: a capillary array-based fluorimetric strategy for high-throughput detection of total iron ions in fish blood.
Analyst
January 2025
Huzhou Key Laboratory of Medical and Environmental Application Technologies, School of Life Sciences, Huzhou University, Huzhou 313000, China.
Water-soluble and biocompatible protein carbon dots (P-CDs) were simply prepared from egg white by a rapid one-step neutralization heat reaction. Unexpectedly, the thus-fabricated P-CDs could present excitation-dependent tunable fluorescence that could be quenched specifically by Fe and Fe ions with obvious color changes. A high-throughput fluorimetric platform was thereby developed by coating the P-CDs onto a capillary array for detection of total iron ions in fish blood samples, with a linear concentration range of 0.
View Article and Find Full Text PDFAdenosine diphosphate stimulates VEGF-independent choroidal endothelial cell proliferation: A potential escape from anti-VEGF therapy.
Proc Natl Acad Sci U S A
January 2025
Department of Pathology, University of California San Diego, La Jolla, CA 92093.
We hypothesized that a strategy employing tissue-specific endothelial cells (EC) might facilitate the identification of tissue- or organ-specific vascular functions of ubiquitous metabolites. An unbiased approach was employed to identify water-soluble small molecules with mitogenic activity on choroidal EC. We identified adenosine diphosphate (ADP) as a candidate, following biochemical purification from mouse EL4 lymphoma extracts.
View Article and Find Full Text PDFCarbonic Anhydrase IX Targeted Polyaspartamide fluorescent Probes for Tumor imaging.
Int J Nanomedicine
January 2025
College of Chemical and Material Engineering, Quzhou University, Quzhou, Zhejiang Province, 324000, People's Republic of China.
Background: Precise intraoperative tumor delineation is essential for successful surgical outcomes. However, conventional methods are often incompetent to provide intraoperative guidance due to lack specificity and sensitivity. Recently fluorescence-guided surgery for tumors to delineate between cancerous and healthy tissues has attracted widespread attention.
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