The initial stages of restoration of hemopoietic microenvironment in a regenerating spleen were studied functionally and morphologically after its partial damage. The hemopoietic microenvironment is restored locally and this process involves the damaged region only. The stages of restoration of hemopoietic microenvironment in the spleen are determined only by the properties of the spleen stroma itself and do not depend on the conditions of regeneration (in situ damage or ectopic transplantation).
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Front Immunol
January 2025
Department of Hematology, Tianjin Medical University General Hospital, Tianjin, China.
In recent years, tumor immunotherapy has become an active research area, with the emergence of immune checkpoint inhibitors (ICIs) revolutionizing immunotherapy. Clinical evidence indicates that programmed cell death protein 1 (PD-1) monoclonal antibodies and other drugs have remarkable therapeutic effects. V-domain Ig suppressor of T-cell activation (VISTA) is a new type of immune checkpoint receptor that is highly expressed in various tumors.
View Article and Find Full Text PDFJ Transl Med
July 2024
Department of Hematology, Tianjin Medical University Tianjin General Hospital, Tianjin, China.
Background: Myelodysplastic syndrome (MDS) is a complicated hematopoietic malignancy characterized by bone marrow (BM) dysplasia with symptoms like anemia, neutropenia, or thrombocytopenia. MDS exhibits considerable heterogeneity in prognosis, with approximately 30% of patients progressing to acute myeloid leukemia (AML). Single cell RNA-sequencing (scRNA-seq) is a new and powerful technique to profile disease landscapes.
View Article and Find Full Text PDFZhonghua Xue Ye Xue Za Zhi
March 2024
Department of Hematology, General Hospital of Tianjin Medical University, Tianjin 300052, China Tianjin Key Laboratory of Bone Marrow Failure and Malignant Hemopoietic Clone Control, Tianjin 300052, China.
J Transl Med
March 2024
Department of Hematology, Tianjin Medical University General Hospital, No.154 Anshan Road, Heping District, Tianjin, 300052, China.
iScience
March 2024
Bone Marrow Transplantation Center, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.
Aging is considered a critical factor of poor prognosis in allogenic hemopoietic stem cell transplantation (allo-HSCT). To elucidate the underlying mechanisms, we comprehensively reintegrated our clinical data from patients after allo-HSCT and public single-cell transcriptomic profile from post-allo-HSCT and healthy individuals, demonstrating that old donors were more prone to acute GVHD (aGVHD) with pronounced inflammation accumulation and worse overall survival (OS). We also found the presence of inflammation-related CXCL2+ HSC subpopulation during aging with significantly enriched pro-inflammatory pathways.
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