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From the second half of the nineteenth-century treatment of "imbecile" children in Britain underwent significant change. Examining the period from 1870 to 1920 when imbecility became a discrete category, and a matter of concern in policy and practice, this paper focuses on conceptualizations around fright, idleness, morality, and parental mental state as behavioral, emotional, and psychological causes and attributions of "imbecility" in children. I view this in light of the Victorian emotional culture of "care and control," which was driven by a shift in cost-cutting and fear of the impact of "imbecile children" on society, justifying exclusions, defining boundaries, and driving change.

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Astrocytes phenomics as new druggable targets in healthy aging and Alzheimer's disease progression.

Front Cell Neurosci

January 2025

Section of Clinical Pharmacology and Oncology, Department of Health Sciences, University of Florence, Florence, Italy.

For over a century after their discovery astrocytes were regarded merely as cells located among other brain cells to hold and give support to neurons. Astrocytes activation, "astrocytosis" or A1 functional state, was considered a detrimental mechanism against neuronal survival. Recently, the scientific view on astrocytes has changed.

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Physicochemical profiles of mixed ruminal microbes in response to surface tension and specific surface area.

Front Vet Sci

January 2025

Facultad de Medicina Veterinaria y Zootecnia, Universidad Autónoma del Estado de México, Toluca, Mexico.

Introduction: In ruminants, a symbiotic rumen microbiota is responsible for supporting the digestion of dietary fiber and contributes to health traits closely associated with meat and milk quality. A holistic view of the physicochemical profiles of mixed rumen microbiota (MRM) is not well-illustrated.

Methods: The experiment was performed with a 3 × 4 factorial arrangement of the specific surface area (SSA: 3.

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Introduction: Parkinson's Disease is the second most common neurodegenerative disease in the world. It affects mainly people over 65 and the incidence increases with age. It is characterized by motor and non-motor symptoms and several clinical manifestations.

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Impact of tunnel enlargement on patient-reported outcomes following isolated posterior cruciate ligament reconstruction.

J Orthop Surg Res

January 2025

Department of Orthopaedics and Traumatology, Taipei Veterans General Hospital, R.O.C, No. 201, Sec. 2, Shih-Pai Road, Beitou District, 112, Taipei, Taiwan.

Background: Tunnel enlargement (TE) might jeopardize knee function and ligament stability after revision surgery of anterior cruciate ligament reconstruction. To date, only few studies concern TE following posterior cruciate ligament reconstruction (PCLR). This study aims to determine TE after isolated PCLR and its relationship with patient-reported outcomes.

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