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Curvisetone─A Male-Specific Tricyclic -Diterpenoid from the Springtail .
J Nat Prod
March 2025
Technische Universität Braunschweig, Institute of Organic Chemistry, Hagenring 30, 38106 Braunschweig, Germany.
The structure determination and occurrence of curvisetone (), a tricyclic nor-diterpenoid from the tiny Collembola , is reported. Utilizing NMR analysis and mass spectrometry, we identified curvisetone's unique carbon skeleton and its occurrence in various sex and life stages. Curvisetone, carrying an unprecedented carbon tricyclic ring system, is an example of the distinct terpene usage of Collembola, which differentiates them from other arthropods.
View Article and Find Full Text PDFCulturally adapted developmental outcome measure for Aboriginal and Torres Strait Islander children: study protocol for the validation of the ASQ-STEPS.
BMJ Open
March 2025
Department of Paediatrics, Faculty of Medicine, Dentistry and Health Sciences, The University of Melbourne, Melbourne, Victoria, Australia.
Introduction: Early childhood education and intervention programmes can improve the developmental outcomes for priority groups of children. However, in Australia, a culturally responsive developmental outcome measure that has been validated for use with Aboriginal and Torres Strait Islander children is required to effectively evaluate impact.The Ages and Stages Questionnaire-Steps for Measuring Aboriginal Child Development (ASQ-STEPS) has been developed to fill this gap.
View Article and Find Full Text PDFInvestigating the Effects of TRPV4 and Ca1.2 Channels in 3D Culture for Promoting the Differentiation of BMSCs at Various Stages.
Exp Cell Res
March 2025
School of Stomatology, Xuzhou Medical University, Xuzhou, 221007, China; Xuzhou Stomatological Hospital, Xuzhou, 221007, China. Electronic address:
Hydrogel, as the most suitable bio-scaffold material for simulating extracellular matrix, can be used to study the influence of material mechanical properties on cell behavior under 3D conditions. Mechanical stimulation plays an important role in cartilage differentiation, especially for the mechanosensitive cell-bone marrow mesenchymal stem cells (BMSCs). Currently, TRPV4 and Cav1.
View Article and Find Full Text PDFCD4 T cells take center stage during dengue infection.
Cell Rep
March 2025
Centre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM), Montréal, QC, Canada; Département de médicine, Université de Montréal, Montréal, QC, Canada. Electronic address:
Ansari et al. identified a subset of CD4 T cells (CXCR5PD-1) resembling T follicular helper (Tfh) cells in patients with severe dengue. This subset helps B cell responses via IL-21 and can also differentiate into cytotoxic CD4 T cells.
View Article and Find Full Text PDFA machine learning-based prognostic signature utilizing MSC proteomics for predicting bladder cancer prognosis and treatment response.
Transl Oncol
March 2025
Institute of Urology, Lanzhou University Second Hospital, Key Laboratory of Gansu Province for Urological Diseases, Gansu Urological Clinical Center, Lanzhou, China. Electronic address:
Background: Mesenchymal stem cells (MSCs), due to their tumor-targeting homing properties, are present in the tumor microenvironment (TME) and influence the biological behaviors of tumors. The purpose of this paper is to establish a signature based on the MSC secretome to predict the prognosis and treatment of bladder cancer (BLCA).
Methods: The presence of MSCs in BLCA was validated through flow cytometry and multiplex fluorescence immunohistochemistry (mFIHC), and the relationships between MSCs and clinical characteristics were explored.
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