A monoclonal antibody known to recognize the H-2.m3 specificity is shown to react with the class I H-2 product of tLub-1 but not tw12tf mice. This reagent was used to study the segregation of the H-2 complex in the progeny of tLub-1 +/tw12tf females. The most straightforward interpretation of the results presented here is that these t haplotypes carry an H-2 complex located between the centromere and tufted locus. Possible consequences of such a location with regard to the recombination between t haplotypes and chromosome 17 from laboratory mice are discussed.
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