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Using the Key Characteristics Framework to Unlock the Mysteries of Aryl Hydrocarbon Receptor-Mediated Effects on the Immune System.
Annu Rev Immunol
January 2025
3Department of Environmental Medicine and Department of Microbiology and Immunology, University of Rochester, Rochester, New York, USA; email:
Initially discovered for its role mediating the deleterious effects of environmental contaminants, the aryl hydrocarbon receptor (AHR) is now known to be a crucial regulator of the immune system. The expanding list of AHR ligands includes synthetic and naturally derived molecules spanning pollutants, phytochemicals, pharmaceuticals, and substances derived from amino acids and microorganisms. The consequences of engaging AHR vary, depending on factors such as the AHR ligand, cell type, immune challenge, developmental state, dose, and timing of exposure relative to the immune stimulus.
View Article and Find Full Text PDFEnormous Out-of-Plane Charge Rectification and Conductance through Two-Dimensional Monolayers.
ACS Nano
January 2025
Department of Electrical Engineering, University at Buffalo, the State University of New York, Buffalo, New York 14260, United States.
Heterogeneous integration of emerging two-dimensional (2D) materials with mature three-dimensional (3D) silicon-based semiconductor technology presents a promising approach for the future development of energy-efficient, function-rich nanoelectronic devices. In this study, we designed a mixed-dimensional junction structure in which a 2D monolayer (e.g.
View Article and Find Full Text PDFQuantitative Analysis of Multi-Elements in a Micron-Sized Single Particle Based on Laser-Induced Breakdown Spectroscopy Signal Enhancement of an Optical Fiber Collimated System.
Anal Chem
January 2025
College of Chemistry and Material Science, Northwest University, Xi'an 710127, China.
With rapid, energy-intensive, and coal-fueled economic growth, global air quality is deteriorating, and particulate matter pollution has emerged as one of the major public health problems worldwide. It is extremely urgent to achieve carbon emission reduction and air pollution prevention and control, aiming at the common problem of weak and unstable signals of characteristic elements in the application of laser-induced breakdown spectroscopy (LIBS) technology for trace element detection. In this study, the influence of the optical fiber collimation signal enhancement method on the LIBS signal was explored.
View Article and Find Full Text PDFUnilateral cleft lip and palate patients present cranial base modifications: a cross-sectional study.
Braz Oral Res
January 2025
Pontifícia Universidade Católica de Minas Gerais - PUC Minas, School of Dentistry, Graduate Program in Dentistry, Belo Horizonte, MG, Brazil.
The aim of this cross-sectional study was to perform a three-dimensional (3D) assessment of the cranial base of patients with unilateral cleft lip and palate (UCLP). Cone-beam computed tomography (CBCT) scans of 52 UCLP patients (21 females and 31 males; mean age, 10.0 ± 2.
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