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Working group summary of the 2023 full update of the Finnish national guidelines for paediatric lower respiratory tract infections.
Acta Paediatr
February 2025
Department of Paediatrics and Adolescent Medicine, Oulu University Hospital, Oulu, Finland.
Article Synopsis
- The 2023 Finnish guidelines for pediatric lower respiratory tract infections (LRTIs) were updated based on a systematic review of strong, moderate, and weak evidence from various studies.
- Key recommendations include avoiding antitussives and beta-sympathomimetics for bronchitis, using oral corticosteroids for laryngitis, and prescribing a 5-day course of amoxicillin for community-acquired pneumonia.
- The goal of the guidelines is to enhance evidence-based treatment for LRTIs in children, focusing on the correct use of antibiotics, inhaled therapies, corticosteroids, and appropriate testing.
SARS-CoV-2 acute bronchiolitis in hospitalized children: Neither frequent nor more severe.
Pediatr Pulmonol
January 2022
Research Institute Hospital 12 de Octubre in Madrid (i+12), Foundation for Biomedical Research of the 12 de Octubre Hospital, Madrid, Spain.
Introduction: Endemic coronaviruses have been found in acute bronchiolitis, mainly as a coinfecting virus. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been responsible for respiratory illness in hospitalized children. The characteristics of patients with bronchiolitis have not been extensively described.
View Article and Find Full Text PDFInvolvement of Gi protein-dependent BK channel activation in β-adrenoceptor-mediated dilation of retinal arterioles in rats.
Naunyn Schmiedebergs Arch Pharmacol
November 2020
Department of Molecular Pharmacology, Kitasato University School of Pharmaceutical Sciences, 5-9-1 Shirokane, Minato-ku, Tokyo, 108-8641, Japan.
Circulating catecholamines contribute to the regulation of retinal vascular tone. Our previous studies have demonstrated that the activation of large-conductance Ca-activated K (BK) channels is involved in the β-adrenoceptor-mediated dilation of retinal arterioles in rats. The present study aimed to examine the role of Gi protein in the β-adrenoceptor-mediated activation of BK channels in the retinal arterioles.
View Article and Find Full Text PDFInvolvement of Allosteric Effect and K Channels in Crosstalk between β₂-Adrenergic and Muscarinic M₂ Receptors in Airway Smooth Muscle.
Int J Mol Sci
July 2018
Division of Clinical Sciences and Neuropsychopharmacology, Graduate School of Pharmacy, Meijo University, 150 Yagotoyama, Tempaku-ku, Nagoya 468-8503, Japan.
To advance the development of bronchodilators for asthma and chronic obstructive pulmonary disease (COPD), this study was designed to investigate the mechanism of functional antagonism between β₂-adrenergic and muscarinic M₂ receptors, focusing on allosteric effects and G proteins/ion channels coupling. Muscarinic receptor antagonists (tiotropium, glycopyrronium, atropine) synergistically enhanced the relaxant effects of β₂-adrenergic receptor agonists (procaterol, salbutamol, formoterol) in guinea pig trachealis. This crosstalk was inhibited by iberitoxin, a large-conductance Ca-activated K⁺ (K) channel inhibitor, whereas it was increased by verapamil, a L-type voltage-dependent Ca (VDC) channel inhibitor; additionally, it was enhanced after tissues were incubated with pertussis or cholera toxin.
View Article and Find Full Text PDFBehavioral Conditioning of Immune Responses with Cyclosporine A in a Murine Model of Experimental Autoimmune Uveitis.
Neuroimmunomodulation
June 2018
Department of Ophthalmology and Ophtha-Lab, St. Franziskus Hospital, Münster, Germany.
Objective: We examined the role of behavioral conditioning of immune responses with cyclosporine A (CsA) on the development of Th1/Th17-driven experimental autoimmune uveoretinitis (EAU).
Methods: Mice received a 0.2% w/v saccharin solution as conditioned stimulus combined with CsA (20 mg/kg) in 6 association trials at 72-h intervals.
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