A right-hemisphere premotor cerebral infarct in a right-handed man from a largely left-handed family caused cortical anarthria and constructional agraphia. The effect of programming difficulties on impaired oral and written expression was demonstrated by the clinical picture of pure agraphia, which could thus be attributed to a primary disorder of programming. Measurements of cerebral blood flow three months after the accident showed that language representation was ambilateral.
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Cureus
August 2024
Research Team in Neurology, Department of Neurology A and Neuropsychology, Faculty of Medicine and Pharmacy, Specialty Hospital, University Mohammed V, Rabat, MAR.
Aceruloplasminemia (ACP) is a rare genetic disorder that manifests in adulthood due to mutations in the CP (ceruloplasmin) gene, causing iron accumulation and neurodegeneration. Clinically, ACP presents with a range of symptoms, including mild microcytic anemia, diabetes mellitus, liver disease, retinopathy, progressive neurological symptoms such as cerebellar ataxia, involuntary movements, parkinsonism, mood and behavior disorders, and cognitive impairment. We present the case of a 53-year-old female with a history of first-degree consanguinity and a sister with anemia.
View Article and Find Full Text PDFNeuropsychologia
June 2024
Neurochirurgia, Dipartimento "Testa, Collo e Neuroscienze", Azienda Sanitaria Universitaria Friuli Centrale ASU FC, Italy.
We retrospectively analyzed data from 15 patients, with a normal pre-operative cognitive performance, undergoing awake surgery for left fronto-temporal low-grade glioma. We combined a pre-surgical measure (fMRI maps of motor- and language-related centers) with intra-surgical measures (MNI-registered cortical sites data obtained during intra-operative direct electrical stimulation, DES, while they performed the two most common language tasks: number counting and picture naming). Selective DES effects along the precentral gyrus/inferior frontal gyrus (and/or the connected speech articulation network) were obtained.
View Article and Find Full Text PDFJ Neurosurg
June 2024
4Neurosurgery Unit, Fondazione IRCCS S. Matteo Polyclinic, Pavia, Italy.
Objective: In this retrospective study, the authors aimed to establish the stereotactically defined probability distribution for speech (i.e., anarthria, speech arrest) and lexico-semantic errors (i.
View Article and Find Full Text PDFBrain Neurorehabil
March 2022
Department of Physical and Rehabilitation Medicine, Center for Prevention and Rehabilitation, Heart Vascular Stroke Institute, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
Anarthria is a complete loss of speech. It usually results from lesions in bilateral neural substrates that control articulation. Recently, lateralized cortical control of speech articulation in the dominant hemisphere has been reported.
View Article and Find Full Text PDFUgeskr Laeger
July 2022
Afdeling for Hjerne- og Nervesygdomme, Københavns Universitetshospital - Rigshospitalet.
Sudden onset anarthria and dysphagia without lateralised neurologic symptoms should prompt an investigation for pseudobulbar palsy, either due to bilateral vascular lesions of the corticobulbar tracts or, less frequently, Foix-Chavany-Marie Syndrome (FCMS). Here, bilateral damage to the frontal opercular cortex leads to loss of voluntary control of muscles supplied by cranial nerves V, VII, IX, X, XI, and XII. This case report presents a rare case of FCMS on the background of traumatic cerebral lesions following a bicycle incident.
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