The effect of methylthiouracil (MTU) on the colloidopexic capacity of rat hepatosplenic macrophages was experimentally studied. MTU administration determined the depression of the colloidopexic function tested with isamine blue. Under such conditions, thyroid insufficiency may be responsible for the decrease of the hepatosplenic colloidopexic activity. X

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The effect of methylthiouracil (MTU) on the colloidopexic capacity of rat hepatosplenic macrophages was experimentally studied. MTU administration determined the depression of the colloidopexic function tested with isamine blue. Under such conditions, thyroid insufficiency may be responsible for the decrease of the hepatosplenic colloidopexic activity.

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The whole-body irradiation of adult Wistar rats with a single dose of 800 r X-rays intensifies the lymph node changes and the decrease of the colloidopexic capacity of hepatosplenic macrophages established by the "reverse" administration of sexual hormones. The modifications observed after estradiol administration to the male rat are more marked after a 6 months' interval than those caused in the same interval by testosterone in the female rat lymph nodes.

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The authors have studied the effect of testosterone administration in male adult Wistar rats irradiated with a single total dose of 800 r X-rays. The results obtained show that testosterone exerts a double radioprotective action. This hormone prevents both the occurrence of the senile type spleen and lymph node changes and the depression of the colloidopexic capacity of the hepatosplenic macrophages.

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