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Rates and Predictors of Malignancy in Bethesda III and IV Thyroid Nodules: A Prospective Study.
Cureus
December 2024
Internal Medicine, University of Alexandria, Alexandria, EGY.
Aim: Thyroid nodules, based on high-resolution ultrasonography (HRUS), are among the most common endocrine abnormalities that affect the general population because of their high estimated prevalence rates. Fine needle aspiration cytology (FNAC) is a safe, cost-effective modality to differentiate between benign and malignant thyroid nodules based on the Bethesda System for Reporting Thyroid Cytopathology (BSRTC), thus avoiding unnecessary surgery. However, categories III and IV of BSRTC remain a controversial issue in clinical practice, encompassing a wide range of risks of malignancy.
View Article and Find Full Text PDFSuppressing Cation Interdiffusion at CeO/ZrO Heterointerfaces via Dopant Segregation.
ACS Appl Mater Interfaces
January 2025
Hydrogen Fuel Cell Laboratory, Korea Institute of Energy Research (KIER), 152 Gajeong-ro, Yuseong-gu, Daejeon 34129, Korea.
Cation interdiffusion as a result of a chemical-potential gradient occurring at heterointerfaces is often regarded as an unfavorable side reaction and is typically suppressed through the use of a diffusion barrier layer. In this study, we propose a straightforward method for suppressing interdiffusion that involves the creation of nanometer-thick diffusion barrier layers by means of dopant segregation. Using the CeO/ZrO heterointerface in this study, we demonstrate that a Sc acceptor dopant tends to accumulate at the heterointerface during the sintering process, especially at the edge of the CeO grain boundary, thereby effectively suppressing Ce-Zr interdiffusion.
View Article and Find Full Text PDFSerum cardiac and inflammatory biomarker levels following chemotherapy among female patients with breast cancer attending at Tikur Anbessa Specialized Hospital, Addis Ababa, Ethiopia.
BMC Cancer
January 2025
Department of Biomedical Sciences, College of Medicine and Health Sciences, Bahir Dar University, Bahir Dar, P.O. Box 79, Ethiopia.
Background: Chemotherapy is a well-established therapeutic approach for several malignancies, including breast cancer (BCa). However, the clinical efficacy of this drug is limited by cardiotoxicity. Assessing multiple cardiac biomarkers can help identify patients at risk of adverse outcomes from chemotherapy.
View Article and Find Full Text PDFIncidence and predictors of adverse birth outcomes among women who gave birth at Assosa general hospital, Northwest Ethiopia: a retrospective cohort study.
BMC Pregnancy Childbirth
January 2025
Department of Public Health, College of Health Science, Assosa University, Benishangul-Gumuz region, Assosa Town, Ethiopia.
Background: Adverse birth outcomes are a significant public health problem worldwide, particularly in low- and middle-income countries. Adverse birth outcomes have significant immediate and long-term health consequences for infants and their families. Understanding the determinants of adverse birth outcomes is crucial to effective interventions.
View Article and Find Full Text PDFSporadic ALS iPSC-derived motor neurons show axonal defects linked to altered axon guidance pathways.
Neurobiol Dis
January 2025
KU Leuven - University of Leuven, Department of Neurosciences and Leuven Brain Institute (LBI), Leuven, Belgium; Laboratory of Neurobiology, VIB Center for Brain & Disease Research, Leuven, Belgium. Electronic address:
Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disorder characterized by the selective and progressive loss of motor neurons, leading to gradual paralysis and death within 2 to 5 years after diagnosis. The exact underlying pathogenic mechanism(s) remain elusive. This is particularly the case for sporadic ALS (sALS), representing 90 % of cases, as modelling a sporadic disease is extremely difficult.
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