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Chloramphenicol and gentamicin reduce the evolution of resistance to phage ΦX174 by suppressing a subset of E. coli LPS mutants.
PLoS Biol
January 2025
Microbial Molecular Evolution Group, Department of Microbial Population Biology, Max Planck Institute for Evolutionary Biology, Plön, Germany.
Bacteriophages infect gram-negative bacteria by attaching to molecules present on the bacterial surface, often lipopolysaccharides (LPS). Modification of LPS can lead to resistance to phage infection. In addition, LPS modifications can impact antibiotic susceptibility, allowing for phage-antibiotic synergism.
View Article and Find Full Text PDFCardiovascular disease risk perception among community-dwelling adults in southwest Nigeria: A mixed-method study.
PLoS One
November 2024
Department of Physiotherapy, College of Medicine, University of Ibadan, Ibadan, Nigeria.
Article Synopsis
- Over a quarter of participants displayed poor awareness of their own CVD risk, with rural residents scoring significantly lower than urban ones in risk perception.
- Key factors influencing better CVD risk perception included having tertiary education, residing in urban areas, and living in specific Nigerian states, indicating a need for enhanced public health education and awareness programs.
A computational model for bacteriophage ϕX174 gene expression.
PLoS One
October 2024
Department of Integrative Biology, The University of Texas at Austin, Austin, TX, United States of America.
Bacteriophage ϕX174 has been widely used as a model organism to study fundamental processes in molecular biology. However, several aspects of ϕX174 gene regulation are not fully resolved. Here we construct a computational model for ϕX174 and use the model to study gene regulation during the phage infection cycle.
View Article and Find Full Text PDFCensorCheck: A Tool for Evaluating Protected Health Information Detection Systems.
Stud Health Technol Inform
September 2024
Identifying protected health identifiers (PHIs) in free text is core to anonymising clinical notes for research. There is no standard metric for the quality of a PHI detection algorithm, resulting in papers reporting heterogeneous results. CensorCheck is presented, which computes specialised metrics for evaluating PHI detection taking into account the peculiarities of anonymisation tasks.
View Article and Find Full Text PDFEfficacy of UVC-LED radiation in bacterial, viral, and protozoan inactivation: an assessment of the influence of exposure doses and water quality.
Water Res
November 2024
Department of Hydraulics and Sanitation, São Carlos School of Engineering, University of São Paulo, Avenida Trabalhador São-Carlense 400, São Carlos, São Paulo, 13566-590, Brazil. Electronic address:
Article Synopsis
- Ultraviolet light-emitting diodes (UV-LEDs) are a promising alternative to traditional mercury lamps for disinfecting water by inactivating microorganisms.
- This study specifically examined the effectiveness of a bench-scale UVC-LED system at 280 nm on various pathogens, including E. coli, PhiX-174, MS2, and Cryptosporidium oocysts, under different water qualities.
- Results showed that while microbiological reductions varied with exposure time and water quality, UVC-LED technology was generally effective in achieving significant reductions of bacteria and viruses, highlighting its potential for use in small water systems as recommended by the World Health Organization.
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