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Hypobaric hypoxia drives selection of altitude-associated adaptative alleles in the Himalayan population.
Sci Total Environ
February 2024
Genomics and Molecular Medicine, CSIR-Institute of Genomics and Integrative Biology, Delhi 110007, India; Institute of Hypoxia Research, New Delhi 110067, India. Electronic address:
Genetic variants play a crucial role in shaping the adaptive phenotypes associated with high-altitude populations. Nevertheless, a comprehensive understanding of the specific impacts of different environments associated with increasing altitudes on the natural selection of these genetic variants remains undetermined. Hence, this study aimed to identify genetic markers responsible for high-altitude adaptation with specific reference to different altitudes, majorly focussing on an altitude elevation range of ∼1500 m and a corresponding decrease of ≥5 % in ambient oxygen availability.
View Article and Find Full Text PDFIn the article by Escudero et al (2006), there are only random samples, which are useful for the validity of the study design. In this author's opinion, there are still other clinicophysiological characteristics that merit consideration and scrutiny as discussed below. The hypothesis set by the original authors needs to be adequately justified.
View Article and Find Full Text PDFSeromucous maxillary sinusitis (SMMS): a clinicophysiological approach.
Acta Otorhinolaryngol Belg
June 2001
Department of Otorhinolaryngology, Medical School University of Ioannina, Ioannina 45 110, Greece.
Chronic sinusitis, especially maxillary sinusitis is a common disorder in humans. Seromucous sinusitis is rarely described in the literature. The present study deals with the clinical and laboratory characteristics of a group of patients suffering from the above disorder.
View Article and Find Full Text PDFCharacteristic modifications of the peripheral airways in patients with bronchial asthma in areas with air pollution.
Respirology
June 2000
World Health Organization Collaborating Center for Research and Training in Diagnostic Endoscopy of Lung Diseases, Tokyo Medical University, Japan.
Objective: Changes in the peripheral airways in patients with bronchial asthma who were living in the Kawasaki industrial zone, region with severe air pollution, were morphologically investigated in order to determine the pathological conditions of such bronchial asthma, in particular ascertaining the effect of air pollution.
Methodology: Studies were made of the morphological characteristics of the peripheral airways in patients with bronchial asthma who had resided for long periods in an area near Tokyo affected by air pollution.
Results: The endoscopic findings of the peripheral airways were distinct, consisting of reddening, stenosis, pigmentation, pallor, lustrelessness and hypersecretion.
Exhaled nitric oxide; relationship to clinicophysiological markers of asthma severity.
Respir Med
July 1998
University Medicine, Southampton General Hospital, U.K.
Bronchial asthma is an airway disorder associated with bronchial hyperresponsiveness, variable airflow obstruction and elevated levels of nitric oxide (NO) in exhaled air. The variables all reflect, in part, the underlying airway inflammation in this disease. To understand their interrelationships we have investigated the relationship between exhaled NO levels and clinicophysiological markers of asthma severity.
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