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Metagenomic Analysis of Gut Microbiome of Persistent Pulmonary Hypertension of the Newborn.
Cardiovasc Toxicol
December 2024
Department of Pediatrics, Ministry of Education Key Laboratory of Women and Children's Diseases and Birth Defects, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, China.
Persistent pulmonary hypertension of the newborn (PPHN) is one of the most common diseases in the neonatal intensive care unit which severely affects neonatal survival. Gut microbes play an increasingly important role in human health, but there are rarely reported how gut microbiota contribute to PPHN. In our study, the metagenomic sequencing of feces from 12 PPHN's neonates and 8 controls were performed to expose the relation between neonatal gut microbes and PPHN disease.
View Article and Find Full Text PDFOccurrence and human exposure risk of antibiotic resistance genes in tillage soils of dryland regions: A case study of northern Ningxia Plain, China.
J Hazard Mater
December 2024
State Key Laboratory of Soil and Sustainable Agriculture, Institute of Soil Science, Chinese Academy of Sciences, Nanjing 211135, China; Jiangsu Collaborative Innovation Center for Solid Organic Waste Resource Utilization, Nanjing 210095, China.
Agricultural soils are important source and sink of antibiotic resistance genes (ARGs). However, little is known about the fate of ARGs in dryland soils, while its human exposure risks were seriously overlooked. Taking the northern Ningxia Plain as a case, this study explored the occurrence of ARGs and its relationship with mobile genetic elements (MGEs), pathogens, and environmental factors.
View Article and Find Full Text PDFThe potential role of lung microbiota and lauroylcarnitine in T-cell activation associated with checkpoint inhibitor pneumonitis.
EBioMedicine
August 2024
Department of Respiratory and Critical Care Medicine, Peking University People's Hospital, Beijing 100044, China. Electronic address:
Background: Checkpoint inhibitor pneumonitis (CIP) is a potentially fatal adverse event characterized by new pulmonary infiltrates in cancer patients receiving immune checkpoint inhibitor therapy. This study aims to explore the interplay between lung microbiota, dysregulated metabolites, and host immunity in CIP.
Methods: We recruited thirteen hospitalized CIP patients, eleven idiopathic pulmonary fibrosis (IPF) patients, and ten new-onset non-small cell lung cancer patients.
Modulation of Gut Microbial Community and Metabolism by HD173 Promotes the Growth of Nursery Piglets Model.
Nutrients
May 2024
College of Animal Sciences and Technology, Huazhong Agricultural University, Wuhan 430070, China.
Article Synopsis
- * HD173 has been shown to improve growth performance and health in piglets by reducing pro-inflammatory cytokines and pathogenic bacteria while promoting beneficial bacteria that enhance butyric acid production.
- * The study suggests that HD173 could be a valuable addition to probiotic products aimed at improving gut health in both humans and animals.
Molecular mechanism of Fe binding inhibition to Vibrio metschnikovii ferric ion-binding protein, FbpA, by rosmarinic acid and its hydrolysate, danshensu.
Protein Sci
February 2024
Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Science, The University of Tokyo, Tokyo, Japan.
Global warming has increased the growth of pathogenic Vibrio bacteria, which can cause foodborne illnesses and death. Vibrio bacteria require iron for growth and survival. They utilize a ferric ion-binding protein (FbpA) to bind and transport Fe into the cell.
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